Bartl R, Hansmann M L, Frisch B, Burkhardt R
Abt. f. Knochenmarksdiagnostik, Medizinische Klinik Innenstadt d.Universität, München.
Br J Haematol. 1988 Jun;69(2):229-37. doi: 10.1111/j.1365-2141.1988.tb07627.x.
Lymph node and bone marrow biopsies of 226 patients with malignant lymphomas were available for evaluation and comparison. 120 of the 226 lymphoma patients had classifiable infiltration in both lymph node and bone marrow and these were used for comparison. Congruence in the histologic subtypes in lymph node and bone marrow was found in 91 patients (76%). The majority of the 29 cases with divergent histologies showed ML of low grade malignancy in the bone marrow even with long time intervals between the two biopsies. The most notable in this group were seven cases who had ML centroblastic/centrocytic in the lymph node biopsy and ML immunocytic in the bone marrow, although none had a serum M-component. 65 of the 106 patients excluded from comparison had involvement in only one organ, the others had unclassifiable or equivocal histologies in either lymph node or bone marrow or in both. The findings are discussed with respect to the histologic behaviour of the lymphomas. The results show that comparison between lymph node and bone marrow findings in patients with ML is feasible and clinically relevant.
对226例恶性淋巴瘤患者的淋巴结和骨髓活检样本进行了评估和比较。226例淋巴瘤患者中，有120例在淋巴结和骨髓中均有可分类的浸润，这些样本用于比较。91例患者（76%）的淋巴结和骨髓组织学亚型一致。29例组织学不同的病例中，大多数即使在两次活检间隔时间较长的情况下，骨髓中仍显示为低级别恶性淋巴瘤。该组中最值得注意的是7例患者，其淋巴结活检显示为中心母细胞/中心细胞性淋巴瘤，而骨髓活检显示为免疫细胞性淋巴瘤，尽管均无血清M成分。被排除在比较之外的106例患者中，65例仅累及一个器官，其他患者在淋巴结或骨髓或两者中具有不可分类或不明确的组织学表现。针对淋巴瘤的组织学行为对这些发现进行了讨论。结果表明，对淋巴瘤患者的淋巴结和骨髓检查结果进行比较是可行的，且具有临床相关性。
