水飞蓟素与神经退行性疾病：治疗潜力和基本分子机制。
Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms.
机构信息
Department of Pharmacology and Toxicology, School of Pharmacy, Medicinal plant and natural products Research Center, Hamadan University of Medical Sciences, Hamadan 6517838678, Iran.
Department of Neuroscience, School of Science and Advanced Technologies in Medicine, Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
出版信息
Phytomedicine. 2020 Dec;79:153320. doi: 10.1016/j.phymed.2020.153320. Epub 2020 Sep 2.
BACKGROUND
Neurodegenerative diseases (NDDs) are primarily characterized by selective neuronal loss in the brain. Alzheimer's disease as the most common NDDs and the most prevalent cause of dementia is characterized by Amyloid-beta deposition, which leads to cognitive and memory impairment. Parkinson's disease is a progressive neurodegenerative disease characterized by the dramatic death of dopaminergic neuronal cells, especially in the SNc and caused alpha-synuclein accumulation in the neurons. Silymarin, an extract from seeds of Silybum marianum, administered mostly for liver disorders and also had anti-oxidant and anti-carcinogenic activities.
PURPOSE
The present comprehensive review summarizes the beneficial effects of Silymarin in-vivo and in-vitro and even in animal models for these NDDs.
METHODS
A diagram model for systematic review is utilized for this search. The research is conducted in the following databases: PubMed, Web of Science, Scopus, and Science Direct.
RESULTS
Based on the inclusion criteria, 83 studies were selected and discussed in this review.
CONCLUSION
Lastly, we review the latest experimental evidences supporting the potential effects of Silymarin, as a neuroprotective agent in NDDs.
背景
神经退行性疾病（NDDs）主要表现为大脑中选择性神经元丧失。阿尔茨海默病是最常见的 NDDs，也是痴呆症最常见的原因，其特征是淀粉样蛋白-β沉积，导致认知和记忆障碍。帕金森病是一种进行性神经退行性疾病，其特征是多巴胺能神经元细胞的急剧死亡，特别是在 SNc 中，导致神经元中α-突触核蛋白的积累。水飞蓟素是从水飞蓟种子中提取的一种物质，主要用于治疗肝脏疾病，也具有抗氧化和抗癌活性。
目的
本综述总结了水飞蓟素在体内和体外，甚至在这些 NDDs 的动物模型中的有益作用。
方法
我们利用系统综述的图表模型进行了这项研究。研究在以下数据库中进行：PubMed、Web of Science、Scopus 和 Science Direct。
结果
根据纳入标准，本研究共选择并讨论了 83 项研究。
结论
最后，我们综述了最新的实验证据，支持水飞蓟素作为神经保护剂在 NDDs 中的潜在作用。
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