School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India; Department of Pharmaceutics, Bengal College of Pharmaceutical Sciences & Research, Durgapur, 713212, West Bengal, India.
Department of Pharmaceutics, Yenepoya Pharmacy College & Research Centre, Yenepoya (Deemed to Be University), Mangalore, Karnataka, 575018, India.
Eur J Pharmacol. 2024 Oct 15;981:176906. doi: 10.1016/j.ejphar.2024.176906. Epub 2024 Aug 16.
Silymarin, a bioflavonoid derived from the Silybum marianum plant, was discovered in 1960. It contains C and has been extensively used as a therapeutic agent against liver-related diseases caused by alcohol addiction, acute viral hepatitis, and toxins-inducing liver failure. Its efficacy stems from its role as a potent anti-oxidant and scavenger of free radicals, employed through various mechanisms. Additionally, silymarin or silybin possesses immunomodulatory characteristics, impacting immune-enhancing and immune-suppressive functions. Recently, silymarin has been recognized as a potential neuroprotective therapy for various neurological conditions, including Parkinson's and Alzheimer's diseases, along with conditions related to cerebral ischemia. Its hepatoprotective qualities, primarily due to its anti-oxidant and tissue-regenerating properties, are well-established. Silymarin also enhances health by modifying processes such as inflammation, β-amyloid accumulation, cellular estrogenic receptor mediation, and apoptotic machinery. While believed to reduce oxidative stress and support neuroprotective mechanisms, these effects represent just one aspect of the compound's multifaceted protective action. This review article further delves into the possibilities of potential therapeutic advancement of silymarin and silibinin for the management of neurodegenerative disorders via mechanics modules.
水飞蓟素是从水飞蓟植物中提取的一种生物类黄酮，于 1960 年被发现。它含有碳，并已被广泛用作治疗酒精中毒、急性病毒性肝炎和毒素诱导的肝衰竭引起的肝脏相关疾病的药物。其功效源于其作为一种有效的抗氧化剂和自由基清除剂的作用，通过各种机制发挥作用。此外，水飞蓟素或水飞蓟宾具有免疫调节特性，影响免疫增强和免疫抑制功能。最近，水飞蓟素已被认为是治疗各种神经疾病的潜在神经保护疗法，包括帕金森病和阿尔茨海默病，以及与脑缺血相关的疾病。其保肝特性主要归因于其抗氧化和组织再生特性，已得到广泛认可。水飞蓟素还通过改变炎症、β-淀粉样蛋白积累、细胞雌激素受体介导和细胞凋亡机制等过程来促进健康。虽然认为它可以减少氧化应激并支持神经保护机制，但这些作用只是该化合物多方面保护作用的一个方面。这篇综述文章进一步探讨了水飞蓟素和水飞蓟宾通过机械模块在治疗神经退行性疾病方面可能具有的潜在治疗进展的可能性。
