UCL Cancer Institute, University College London, London, UK.
Royal Surrey County Hospital, Surrey, UK.
Ann Palliat Med. 2021 May;10(5):5988-6001. doi: 10.21037/apm-20-919. Epub 2020 Sep 7.
In the United States of America, almost 150,000 people are estimated to be diagnosed with colorectal cancer in 2020 and up to 35% of those are expected to present with oligometastatic disease. The term 'oligometastasis' was first used in 1995, however surgical literature describing liver resection for colorectal cancer dates back to the 1940s. Five-year survival rates of up to 42% with surgery alone for solitary lesions are reported. Modern trials have demonstrated median overall survival rates of over 80 months for patients with colorectal liver metastases treated with perioperative chemotherapy. Colorectal liver metastases have accordingly been described as 'proof of concept' for the oligometastatic theory.
据估计,在 2020 年,美国有近 150000 人被诊断患有结直肠癌,其中多达 35%的人预计患有寡转移疾病。“寡转移”一词最早于 1995 年使用,然而,描述结直肠癌肝切除术的外科文献可以追溯到 20 世纪 40 年代。报道称,对于单个病变,单独手术的 5 年生存率高达 42%。现代试验表明,接受围手术期化疗的结直肠癌肝转移患者的中位总生存率超过 80 个月。因此,结直肠肝转移被描述为寡转移理论的“概念验证”。