Gui Weiwei, Wang Xiaoyue, Luo Yizhou, Wang Jian
Department of Oncology, The Air Force Hospital from Eastern Theater of PLA, Nanjing, China.
Department of Oncology, The Fifth People's Hospital of Changshu, Changshu, China.
Ann Palliat Med. 2020 Sep;9(5):3271-3277. doi: 10.21037/apm-20-1389. Epub 2020 Sep 3.
Our study aims to investigate the level of platelet to lymphocyte ratio (PLR) and determine its prognostic value in patients with advanced colorectal cancer undergoing palliative treatment.
One hundred and fifty-two patients with advanced colorectal cancer confirmed in our hospital from January 2013 to January 2018 were selected as study participants. The boundary-value of PLR was determined by receiver operating characteristics (ROC) curves. Furthermore, the relationship between PLR and clinical characteristics of patients with advanced colorectal cancer was analyzed. Next, the prognostic factors affecting the survival time were analyzed by Kaplan-Meier single factor survival analysis and Cox multivariate regression model.
According to the ROC curve, the optimal critical value of PLR was 207.29. Patients were divided into high PLR (n=73) and low PLR (n=79) groups. The median survival time was 68.0 (24.5, 296.5) days for the high PLR group, and 124 (34, 438) days for the low PLR group and differences between the groups were statistically significant (P<0.05). Both groups had similar demographic features, namely gender, age, Eastern Cooperative Oncology Group (ECOG) score, and several metastasis sites (P>0.05). Albumin and hemoglobin levels were found to be negatively correlated to PLR (P<0.05). Cox multivariate regression model results showed that PLR, albumin, and ECOG score were independent prognostic factors (P<0.05).
This study demonstrated that PLR is an independent prognostic factor of survival time, with good predictive value, in patients with advanced colorectal cancer undergoing palliative treatment. High PLR was significantly correlated to reduced survival rates, while low PLR was associated with better longterm survival rates.
我们的研究旨在调查血小板与淋巴细胞比值（PLR）水平，并确定其在接受姑息治疗的晚期结直肠癌患者中的预后价值。
选取2013年1月至2018年1月在我院确诊的152例晚期结直肠癌患者作为研究对象。通过受试者工作特征（ROC）曲线确定PLR的临界值。此外，分析PLR与晚期结直肠癌患者临床特征之间的关系。接下来，通过Kaplan-Meier单因素生存分析和Cox多因素回归模型分析影响生存时间的预后因素。
根据ROC曲线，PLR的最佳临界值为207.29。患者分为高PLR组（n=73）和低PLR组（n=79）。高PLR组的中位生存时间为68.0（24.5，296.5）天，低PLR组为124（34，438）天，两组之间差异有统计学意义（P<0.05）。两组在人口统计学特征方面相似，即性别、年龄、东部肿瘤协作组（ECOG）评分和转移部位数量（P>0.05）。发现白蛋白和血红蛋白水平与PLR呈负相关（P<0.05）。Cox多因素回归模型结果显示，PLR、白蛋白和ECOG评分是独立的预后因素（P<0.05）。
本研究表明，PLR是接受姑息治疗的晚期结直肠癌患者生存时间的独立预后因素，具有良好的预测价值。高PLR与生存率降低显著相关，而低PLR与较好的长期生存率相关。
