骨髓移植动力学：当祖细胞扩增占主导地位时。
Bone Marrow Transplantation Dynamics: When Progenitor Expansion Prevails.
机构信息
Department of Microscopic and Developmental Anatomy, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666, Japan.
International Research Center for Medical Sciences, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto City 860-0811, Japan; Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail 1902, Bangladesh.
出版信息
Trends Cell Biol. 2020 Nov;30(11):835-836. doi: 10.1016/j.tcb.2020.08.006. Epub 2020 Sep 10.
The transplantation of healthy hematopoietic stem cells (HSCs) contained in the bone marrow is a frontline treatment option for hematopoietic diseases. Detailed analysis of post-transplant HSC kinetics is crucial as the initial engraftment of HSCs influences prognosis. Dong et al. have explored the dynamic change in HSC cell fate upon bone marrow transplantation through the utilization of single-cell transcriptomic analysis.
骨髓中健康造血干细胞（HSCs）的移植是治疗血液疾病的一线选择。详细分析移植后 HSC 的动力学变化至关重要，因为 HSC 的初始植入会影响预后。董等人通过单细胞转录组分析探索了骨髓移植后 HSC 细胞命运的动态变化。
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