Ikeda S, Itoh H, Oohata Y, Nakayama F
Department of Surgery I, Kyushu University Faculty of Medicine, Fukuoka, Japan.
Dis Colon Rectum. 1988 Jul;31(7):541-5. doi: 10.1007/BF02553728.
The effect of a new prostacyclin analogue OP-41483 on ischemic colonic anastomosis was investigated in dogs. Colonic ischemia was produced by devascularization of the marginal vessels in the left colon and graded into three degrees by measuring colonic blood flow with a hydrogen gas clearance method. The agent was administered intravenously after devascularization using a continuous infusion pump. The parameters studied were colonic blood flow in the submucosal layer, rate of anastomotic leakage, beta-glucuronidase activity and protein content of the colonic mucosa, and histologic changes. After administration of the agent, blood flow increased significantly and beta-glucuronidase activity at the anastomotic site was well preserved at a relatively high level in spite of ischemic change. The anastomotic leakage rate was significantly decreased. The present study proved that administration of this new prostacyclin analogue minimizes ischemic damage, and may be of considerable importance in ischemic colonic anastomoses.
在犬身上研究了一种新的前列环素类似物OP - 41483对缺血性结肠吻合术的影响。通过使左结肠边缘血管缺血来造成结肠缺血，并采用氢气清除法测量结肠血流量，将其分为三个程度。在血管缺血后，使用连续输注泵静脉给予该药物。研究的参数包括黏膜下层的结肠血流量、吻合口漏出率、结肠黏膜的β - 葡萄糖醛酸酶活性和蛋白质含量以及组织学变化。给予该药物后，血流量显著增加，尽管存在缺血性改变，但吻合口处的β - 葡萄糖醛酸酶活性仍保持在相对较高水平。吻合口漏出率显著降低。本研究证明，给予这种新的前列环素类似物可将缺血性损伤降至最低，在缺血性结肠吻合术中可能具有相当重要的意义。
