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决奈达隆介导的急性肝毒性和肾毒性。

Dronedarone-Mediated Acute Hepatic and Renal Toxicity.

作者信息

Khan Zarak H, Mukhtar Kashif, Ahmed Munis M, Zaidi Syeda Ramsha, Abd Algayoum Randa

机构信息

Internal Medicine, St. Mary Mercy Hospital, Livonia, USA.

Internal Medicine, King Edward Medical University, Lahore, PAK.

出版信息

Cureus. 2020 Aug 7;12(8):e9611. doi: 10.7759/cureus.9611.

DOI:10.7759/cureus.9611
PMID:32923213
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7478565/
Abstract

Dronedarone, a drug similar in chemical properties to amiodarone, was designed to have similar pharmacodynamic properties as amiodarone with fewer side effects. Although there have been cases of chronic liver enzyme elevation with dronedarone, only a few cases have been reported in literature where it has led to rapid onset of liver failure. We present the case of an 86-year-old male who developed acute liver failure concomitantly with acute kidney failure after he was started on dronedarone therapy.

摘要

决奈达隆是一种化学性质与胺碘酮相似的药物，其设计目的是具有与胺碘酮相似的药效学特性，但副作用较少。尽管有使用决奈达隆后慢性肝酶升高的病例，但文献中仅报道了少数几例导致肝功能衰竭快速发作的情况。我们报告了一例86岁男性患者的病例，该患者在开始决奈达隆治疗后同时出现了急性肝功能衰竭和急性肾衰竭。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f48/7478565/6303f834ad50/cureus-0012-00000009611-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f48/7478565/201789fd1abc/cureus-0012-00000009611-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f48/7478565/6303f834ad50/cureus-0012-00000009611-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f48/7478565/201789fd1abc/cureus-0012-00000009611-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f48/7478565/6303f834ad50/cureus-0012-00000009611-i02.jpg

相似文献

1
Dronedarone-Mediated Acute Hepatic and Renal Toxicity.决奈达隆介导的急性肝毒性和肾毒性。
Cureus. 2020 Aug 7;12(8):e9611. doi: 10.7759/cureus.9611.
2
The use of dronedarone for recurrent ventricular tachycardia: a case report and review of the literature.决奈达隆用于复发性室性心动过速：一例病例报告及文献综述
BMC Res Notes. 2016 Jul 27;9:370. doi: 10.1186/s13104-016-2116-1.
3
Mechanisms of hepatocellular toxicity associated with dronedarone--a comparison to amiodarone.与多非利特相关的肝细胞毒性的作用机制——与胺碘酮的比较。
Toxicol Sci. 2013 Feb;131(2):480-90. doi: 10.1093/toxsci/kfs298. Epub 2012 Nov 7.
4
Severe toxic hepatitis associated with dronedarone.与决奈达隆相关的严重中毒性肝炎。
Curr Drug Saf. 2013 Jul;8(3):201-2. doi: 10.2174/15748863113089990031.
5
Concomitant Acute Hepatic Failure and Renal Failure Induced by Intravenous Amiodarone: A Case Report and Literature Review.静脉注射胺碘酮所致急性肝衰竭和肾衰竭并存：一例报告及文献综述
Gastroenterology Res. 2020 Feb;13(1):40-43. doi: 10.14740/gr1254. Epub 2020 Feb 1.
6
Dronedarone, amiodarone and other antiarrhythmic drugs, and acute liver injuries: a case-referent study.多非利特、胺碘酮和其他抗心律失常药物与急性肝损伤：病例对照研究。
Int J Cardiol. 2018 Sep 1;266:100-105. doi: 10.1016/j.ijcard.2018.04.007.
7
Torsade de pointes tachycardia in a patient on dronedarone therapy.接受决奈达隆治疗的患者发生尖端扭转型室性心动过速。
Pharmacotherapy. 2015 May;35(5):e61-5. doi: 10.1002/phar.1573. Epub 2015 Mar 30.
8
Chronic Digoxin Toxicity Precipitated by Dronedarone.决奈达隆引发的慢性地高辛中毒
Ann Pharmacother. 2014 Jul;48(7):923-927. doi: 10.1177/1060028014530106. Epub 2014 Mar 31.
9
Risk of Cardiovascular Events, Stroke, Congestive Heart Failure, Interstitial Lung Disease, and Acute Liver Injury: Dronedarone versus Amiodarone and Other Antiarrhythmics.心血管事件、中风、充血性心力衰竭、间质性肺疾病和急性肝损伤的风险：决奈达隆与胺碘酮及其他抗心律失常药物的比较
J Atr Fibrillation. 2013 Dec 31;6(4):890. doi: 10.4022/jafib.890. eCollection 2013 Dec.
10
Dronedarone: a promising alternative for the management of atrial fibrillation.多非利特：心房颤动治疗的一种有前途的替代药物。
Cardiovasc Drugs Ther. 2009 Oct;23(5):385-93. doi: 10.1007/s10557-009-6189-0.

本文引用的文献

1
Amiodarone and dronedarone: An update.胺碘酮和决奈达隆：更新。
Trends Cardiovasc Med. 2016 Oct;26(7):597-602. doi: 10.1016/j.tcm.2016.03.014. Epub 2016 Apr 4.
2
Acute renal failure in patients treated with dronedarone or amiodarone: a large population-based cohort study in Italy.决奈达隆或胺碘酮治疗患者的急性肾衰竭：意大利一项基于大人群的队列研究
Eur J Clin Pharmacol. 2015 Sep;71(9):1147-53. doi: 10.1007/s00228-015-1903-2. Epub 2015 Jul 15.
3
Effect of dronedarone on clinical end points in patients with atrial fibrillation and coronary heart disease: insights from the ATHENA trial.
达比加群酯对合并冠心病的心房颤动患者临床终点的影响：来自 ATHENA 试验的观察。
Europace. 2014 Feb;16(2):174-81. doi: 10.1093/europace/eut293. Epub 2013 Sep 26.
4
Reversible acute kidney injury requiring haemodialysis five days after starting dronedarone in a stable 71-year-old man at risk of cardiovascular polypharmacy.
J R Coll Physicians Edinb. 2013;43(2):122-5. doi: 10.4997/JRCPE.2013.207.
5
Drug safety evaluation of dronedarone in atrial fibrillation.达比加群酯在心房颤动中的药物安全性评价。
Expert Opin Drug Saf. 2012 Nov;11(6):1023-45. doi: 10.1517/14740338.2012.722994. Epub 2012 Sep 13.
6
Acute liver failure associated with dronedarone.
Circ Arrhythm Electrophysiol. 2011 Aug;4(4):592-3. doi: 10.1161/CIRCEP.111.963447.
7
Worsening heart failure in the setting of dronedarone initiation.在使用决奈达隆时出现心力衰竭恶化。
Ann Pharmacother. 2010 Sep;44(9):1496-500. doi: 10.1345/aph.1P075. Epub 2010 Jul 13.
8
Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter.决奈达隆用于维持心房颤动或心房扑动的窦性心律。
N Engl J Med. 2007 Sep 6;357(10):987-99. doi: 10.1056/NEJMoa054686.
9
The novel antiarrhythmic drug dronedarone: comparison with amiodarone.新型抗心律失常药物决奈达隆：与胺碘酮的比较。
Cardiovasc Drug Rev. 2005 Fall;23(3):217-30. doi: 10.1111/j.1527-3466.2005.tb00167.x.