大鼠肝移植诱导移植耐受的机制：血清因子参与克隆清除。
Mechanisms of transplantation tolerance induced by liver grafting in rats: involvement of serum factors in clonal deletion.
作者信息
Kamada N, Sumimoto R, Baguerizo A, Yoshimatsu A, Teramoto K, Yamaguchi A
机构信息
Department of Experimental Surgery, National Children's Medical Research Center, Tokyo, Japan.
出版信息
Immunology. 1988 Jun;64(2):315-7.
Abstract
An adoptive transfer assay system was used to investigate the ability of serum from tolerant, liver-grafted rats to inactivate normal thoracic duct lymphocytes. PVG rats were rendered tolerant of DA alloantigens by liver grafting. Serum taken from such rats was used to treat normal PVG thoracic duct lymphocytes (TDL) in vitro and the transplant reactivity of the cells then tested in an adoptive transfer assay. Specific decreased responsiveness compared with TDL treated with normal sera was observed, indicating the functional elimination of alloreactive clones by agents in liver-graft serum.
摘要
采用过继转移试验系统来研究来自耐受肝移植大鼠的血清使正常胸导管淋巴细胞失活的能力。通过肝移植使PVG大鼠对DA同种异体抗原产生耐受。取此类大鼠的血清在体外处理正常PVG胸导管淋巴细胞（TDL），然后在过继转移试验中检测细胞的移植反应性。观察到与用正常血清处理的TDL相比，反应性特异性降低，表明肝移植血清中的因子功能性消除了同种反应性克隆。
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