北仑霉素，一种从红树林来源的菌株2BBP-J2中分离得到的新型弗吉尼亚霉素类抗生素及其通过抑制蛋白质翻译发挥的抗菌活性。
Beilunmycin, a new virginiamycins antibiotic from mangrove-derived sp. 2BBP-J2 and the antibacterial activity by inhibiting protein translation.
作者信息
Jiang Zhong-Ke, Hu Xin-Xin, Xiao Lan-Lin, Ren Yi-Ru, Shakhtina Anna N, Lukianov Dmitrii A, Osterman Ilya A, Sergiev Petr V, Dontsova Olga A, Wang Hao, Wu Gang, You Xue-Fu, Sun Cheng-Hang
机构信息
Department of Microbial Chemistry, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
出版信息
J Asian Nat Prod Res. 2021 Oct;23(10):992-1000. doi: 10.1080/10286020.2020.1810669. Epub 2020 Sep 14.
One new virginiamycin derivative, 'beilunmycin' (), and three known virginiamycin antibiotics, 16-hydroxy-virginiamycin M1 (), virginiamycin M2 (), and virginiamycin M1 (), were isolated from the culture of a mangrove-derived endophytic sp. 2BBP-J2. The structures were characterized on the basis of their spectroscopic data, and the absolute configuration of was established by ECD calculations. Compounds - exhibited antibacterial activities against Gram-positive bacteria, with MIC values in the range of 0.5-16 μg/ml. All the compounds demonstrated strong protein translation-stalling activity, with minimal concentrations detected with pDualrep2 in the range of 1.9-5.9 nmol.
从一株来源于红树林的内生菌sp. 2BBP-J2的培养物中分离得到一种新的维吉尼亚霉素衍生物“北仑霉素”（），以及三种已知的维吉尼亚霉素类抗生素，16-羟基维吉尼亚霉素M1（）、维吉尼亚霉素M2（）和维吉尼亚霉素M1（）。通过光谱数据对其结构进行了表征，并通过电子圆二色光谱（ECD）计算确定了的绝对构型。化合物 - 对革兰氏阳性菌表现出抗菌活性，最低抑菌浓度（MIC）值在0.5 - 16μg/ml范围内。所有化合物均表现出很强的蛋白质翻译停滞活性，用pDualrep2检测到的最低浓度在1.9 - 5.9nmol范围内。
Zotero 插件