Jiang Zhong-Ke, Hu Xin-Xin, Xiao Lan-Lin, Ren Yi-Ru, Shakhtina Anna N, Lukianov Dmitrii A, Osterman Ilya A, Sergiev Petr V, Dontsova Olga A, Wang Hao, Wu Gang, You Xue-Fu, Sun Cheng-Hang
Department of Microbial Chemistry, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
J Asian Nat Prod Res. 2021 Oct;23(10):992-1000. doi: 10.1080/10286020.2020.1810669. Epub 2020 Sep 14.
One new virginiamycin derivative, 'beilunmycin' (), and three known virginiamycin antibiotics, 16-hydroxy-virginiamycin M1 (), virginiamycin M2 (), and virginiamycin M1 (), were isolated from the culture of a mangrove-derived endophytic sp. 2BBP-J2. The structures were characterized on the basis of their spectroscopic data, and the absolute configuration of was established by ECD calculations. Compounds - exhibited antibacterial activities against Gram-positive bacteria, with MIC values in the range of 0.5-16 μg/ml. All the compounds demonstrated strong protein translation-stalling activity, with minimal concentrations detected with pDualrep2 in the range of 1.9-5.9 nmol.
从一株来源于红树林的内生菌sp. 2BBP-J2的培养物中分离得到一种新的维吉尼亚霉素衍生物“北仑霉素”（），以及三种已知的维吉尼亚霉素类抗生素，16-羟基维吉尼亚霉素M1（）、维吉尼亚霉素M2（）和维吉尼亚霉素M1（）。通过光谱数据对其结构进行了表征，并通过电子圆二色光谱（ECD）计算确定了的绝对构型。化合物 - 对革兰氏阳性菌表现出抗菌活性，最低抑菌浓度（MIC）值在0.5 - 16μg/ml范围内。所有化合物均表现出很强的蛋白质翻译停滞活性，用pDualrep2检测到的最低浓度在1.9 - 5.9nmol范围内。
