Giraldi Luca, Stojanovic Jovana, Arzani Dario, Persiani Roberto, Hu Jinfu, Johnson Kenneth C, Zhang Zuo-Feng, Ferraroni Monica, Palli Domenico, Yu Guo-Pei, La Vecchia Carlo, Pelucchi Claudio, Lunet Nuno, Ferro Ana, Malekzadeh Reza, Muscat Joshua, Zaridze David, Maximovich Dmitry, Aragones Nuria, Martin Vicente, Vioque Jesùs, Navarrete-Munoz Eva M, Pakseresht Mohammadreza, Negri Eva, Rota Matteo, Pourfarzi Farhad, Mu Lina, Kurtz Robert C, Lagiou Areti, Lagiou Pagona, Pastorino Roberta, Boccia Stefania
Sezione di Igiene, Istituto di Sanità Pubblica, Università Cattolica del Sacro Cuore.
Department of Health, Kinesiology, and Applied Physiology, Concordia University, Montreal.
Eur J Cancer Prev. 2023 May 1;32(3):215-221. doi: 10.1097/CEJ.0000000000000613. Epub 2020 Sep 10.
The association between height and risk of gastric cancer has been studied in several epidemiological studies with contrasting results. The aim of this study is to examine the association between adult height and gastric cancer within a large pooled analysis of case-control studies members of the Stomach cancer Pooling (StoP) Project consortium.
Data from 18 studies members of the StoP consortium were collected and analyzed. A multivariable logistic regression model was used to estimate the study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between 10-cm increase in height and risk of gastric cancer. Age, sex, tobacco smoking, alcohol consumption, social class, geographical area and Helicobacter pylori (H. pylori ) status were included in the regression model. Resulting estimates were then pooled with random-effect model. Analyses were conducted overall and in strata of selected variables.
A total of 7562 cases and 19 033 controls were included in the analysis. The pooled OR was 0.96 (95% CI 0.87-1.05). A sensitivity analysis was performed restricting the results to the studies with information on H. pylori status, resulting in an OR of 0.97 (95% CI 0.79-1.20).
Our study does not support a strong and consistent association between adult height and gastric cancer.
多项流行病学研究探讨了身高与胃癌风险之间的关联，但结果相互矛盾。本研究旨在通过对胃癌合并（StoP）项目联盟病例对照研究成员进行大规模汇总分析，来检验成人身高与胃癌之间的关联。
收集并分析了StoP联盟18个研究成员的数据。采用多变量逻辑回归模型，估计身高每增加 10 厘米与胃癌风险之间关联的研究特异性比值比（OR）和 95%置信区间（CI）。回归模型纳入了年龄、性别、吸烟、饮酒、社会阶层、地理区域和幽门螺杆菌（H. pylori）感染状况。然后用随机效应模型对所得估计值进行汇总。对总体及选定变量分层进行分析。
分析共纳入 7562 例病例和 19033 例对照。汇总后的 OR 为 0.96（95%CI 0.87 - 1.05）。进行了一项敏感性分析，将结果限定于有幽门螺杆菌感染状况信息的研究，得出的 OR 为 0.97（95%CI 0.79 - 1.20）。
我们的研究不支持成人身高与胃癌之间存在强而一致的关联。
