Department of Clinical Sciences and Community Health, Branch of Medical Statistics, Biometry and Epidemiology "G.A. Maccacaro", University of Milan, Milan, Italy.
Hellenic Health Foundation, Athens, Greece.
Br J Cancer. 2022 Sep;127(4):726-734. doi: 10.1038/s41416-022-01856-w. Epub 2022 May 24.
Evidence from epidemiological studies on the role of tea drinking in gastric cancer risk remains inconsistent. We aimed to investigate and quantify the relationship between tea consumption and gastric cancer in the Stomach cancer Pooling (StoP) Project consortium.
A total of 9438 cases and 20,451 controls from 22 studies worldwide were included. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) of gastric cancer for regular versus non-regular tea drinkers were estimated by one and two-stage modelling analyses, including terms for sex, age and the main recognised risk factors for gastric cancer.
Compared to non-regular drinkers, the estimated adjusted pooled OR for regular tea drinkers was 0.91 (95% CI: 0.85-0.97). When the amount of tea consumed was considered, the OR for consumption of 1-2 cups/day was 1.01 (95% CI: 0.94-1.09) and for >3 cups/day was 0.91 (95% CI: 0.80-1.03). Stronger inverse associations emerged among regular drinkers in China and Japan (OR: 0.67, 95% CI: 0.49-0.91) where green tea is consumed, in subjects with H. pylori infection (OR: 0.68, 95% CI: 0.58-0.80), and for gastric cardia cancer (OR: 0.64, 95% CI: 0.49-0.84).
Our results indicate a weak inverse association between tea consumption and gastric cancer.
来自流行病学研究的证据表明，饮茶与胃癌风险之间的关系仍不一致。我们旨在调查和量化胃癌池（StoP）项目联盟中饮茶与胃癌之间的关系。
共纳入来自全球 22 项研究的 9438 例病例和 20451 例对照。通过一阶段和两阶段建模分析，包括性别、年龄和胃癌的主要公认危险因素等因素，估计经常饮茶者与非经常饮茶者相比胃癌的比值比（OR）及其相应的 95%置信区间（CI）。
与非经常饮茶者相比，经常饮茶者的调整后估计合并 OR 为 0.91（95%CI：0.85-0.97）。当考虑饮茶量时，每天饮用 1-2 杯的 OR 为 1.01（95%CI：0.94-1.09），每天饮用>3 杯的 OR 为 0.91（95%CI：0.80-1.03）。在中国和日本（经常饮用绿茶的地方）、幽门螺杆菌感染患者（OR：0.68，95%CI：0.58-0.80）以及贲门胃癌患者（OR：0.64，95%CI：0.49-0.84）中，经常饮茶者的关联更为强烈。
我们的结果表明，饮茶与胃癌之间存在弱的负相关关系。
