Monroe J G, Seyfert V L
Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia.
Immunol Res. 1988;7(2):136-51. doi: 10.1007/BF02918097.
Studies from a number of laboratories have firmly established the potential of surface immunoglobulin-generated signals in B lymphocyte activation. While clearly there are multiple ways of activating B lymphocytes, some of which may not involve surface immunoglobulin, it is clear that crosslinking of surface immunoglobulin whether by antigen or antireceptor antibody can generate signals relevant to B cell activation. Although considerable insight into the mechanism of transduction of mIg-generated signals across the plasma membrane has been realized, a molecular explanation for linking inositol phospholipid hydrolysis to changes within the cytoplasm and nucleus of the B cell is still speculative. A more rigorous definition of the PKC and calcium components of the mIg signal transduction pathway are critical for a thorough understanding of the mechanism of signal transduction by this receptor. The use of tumor cell models allowing selection of mutants within the signalling pathway(s) will be invaluable to fully defining the critical molecular and biochemical events involved in B cell activation.
多个实验室的研究已确凿证实表面免疫球蛋白产生的信号在B淋巴细胞激活中的潜力。虽然显然存在多种激活B淋巴细胞的方式，其中一些可能不涉及表面免疫球蛋白，但很明显，表面免疫球蛋白无论是通过抗原还是抗受体抗体进行交联，都能产生与B细胞激活相关的信号。尽管对跨质膜转导mIg产生信号的机制已有相当深入的了解，但将肌醇磷脂水解与B细胞胞质和细胞核内变化联系起来的分子解释仍属推测。更严格地定义mIg信号转导途径中的PKC和钙成分，对于全面理解该受体的信号转导机制至关重要。利用肿瘤细胞模型来选择信号通路中的突变体，对于充分确定B细胞激活所涉及的关键分子和生化事件将具有极大价值。
