A Potential MRI Agent and an Anticancer Drug Encapsulated within CPMV Virus-Like Particles.
作者信息
Aljabali Alaa A A, Alzoubi Lorca, Hamzat Yassmen, Alqudah Alaa, Obeid Mohammad A, Al Zoubi Mazhar S, Ennab Raed M, Alshaer Walhan, Albatayneh Khaled, Al-Trad Bahaa, Alqudah Dana A, Chellappan Dinesh Kumar, Gupta Gaurav, Tambuwala Murtaza M, Kamal Dua, Evans David J
机构信息
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan.
Department of Medicinal Chemistry & Pharmacognosy, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan.
出版信息
Comb Chem High Throughput Screen. 2021;24(10):1557-1571. doi: 10.2174/1386207323666200914110012.
BACKGROUND
Virus nanoparticles have been extensively studied over the past decades for theranostics applications. Viruses are well-characterized, naturally occurring nanoparticles that can be produced in high quantity with a high degree of similarity in both structure and composition.
OBJECTIVES
The plant virus Cowpea Mosaic Virus (CPMV) has been innovatively used as a nanoscaffold. Utilization of the internal cavity of empty Virus-Like Particles (VLPs) for the inclusion of therapeutics within the capsid has opened many opportunities in drug delivery and imaging applications.
METHODS
The encapsidation of magnetic materials and anticancer drugs was achieved. CPMV denotes molecules attached to the external surface of CPMV and CPMV denotes molecules within the interior of the capsid.
RESULTS
Here, the generation of novel VLPs incorporating iron-platinum nanoparticles CPMV and cisplatin (Cis) (CPMV) is reported. CPMV exhibited a cytotoxic IC of CPMV on both A549 and MDA-MB-231 cell lines of 1.8 μM and 3.9 μM, respectively after 72 hours of incubation. The CPMV were prepared as potential MRI contrast agents.
CONCLUSION
Cisplatin loaded VLP (CPMV) is shown to enhance cisplatin cytotoxicity in cancer cell lines with its potency increased by 2.3-folds.
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