Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan.
Department of Pharmacy Practice, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan.
Microb Pathog. 2022 Dec;173(Pt A):105799. doi: 10.1016/j.micpath.2022.105799. Epub 2022 Sep 28.
The detection of >400 Monkeypox virus cases in the month of May 2022 and increase to 57,527. confirmed cases by September 9th 2022, across the world, emphasizes the need of new therapeutics for this emerging viral epidemic in humans. Largely the cases seen in Europe, Australia and America are among men who have sex with men making transmission through intimate contact with infectious skin lesions the likely mode of transmission. This implies that this high human-to-human transmission observed in the young Caucasian clusters, and the probable community transmission without any history of travelling to endemic areas would suggest that the epidemic is likely to be sustained human-to-human transmission and unlikely one that would be a short-lasting epidemic. This might necessitate the need for new therapeutic approaches and agents for prophylaxis and treatment of acute infections which is the focus of this review article.
2022 年 5 月，全球已检测到超过 400 例猴痘病毒病例，到 2022 年 9 月 9 日，确诊病例已增至 57527 例。这凸显了人类新兴病毒疫情需要新的治疗方法。在欧洲、澳大利亚和美洲，主要是与男性发生性关系的男性，通过与传染性皮肤损伤的亲密接触传播，可能是主要的传播途径。这意味着在年轻的白人群体中观察到的这种高人际传播，以及在没有前往流行地区旅行史的情况下可能发生的社区传播，表明这种疫情可能是持续的人际传播，而不是短暂的流行。这可能需要新的治疗方法和预防及治疗急性感染的药物，这是本文综述的重点。
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