肾上腺素能耗竭期间新生羊和成年羊对自主神经刺激的心血管反应性。

Cardiovascular reactivity of neonatal and adult sheep to autonomic stimuli during adrenergic depletion.

作者信息

Woods J R, Dandavino A, Nuwayhid B, Brinkman C R, Assali N S

出版信息

Biol Neonate. 1978;34(3-4):112-20. doi: 10.1159/000241114.

Abstract

The cardiovascular responses of the neonatal and adult sheep to autonomic agonists and antagonists were studied in the resting state and following adrenergic neuronal depletion with reserpine. Both the neonates and adults showed similar supersensitivity of the effector system of the peripheral circulation to alpha adrenergic stimulation with catecholamines. In addition, the neonates exhibited supersensitivity of the myocardial effector system to beta-adrenergic stimulation. Unusual finding was a marked supersensitivity of the heart and peripheral circulation to cholinergic receptor blockade with atropine, the mechanisms of which are as yet unclear.

摘要

研究了新生和成年绵羊在静息状态下以及用利血平耗竭肾上腺素能神经元后对自主激动剂和拮抗剂的心血管反应。新生羊和成年羊的外周循环效应系统对儿茶酚胺的α肾上腺素能刺激均表现出相似的超敏反应。此外，新生羊的心肌效应系统对β肾上腺素能刺激表现出超敏反应。一个不寻常的发现是心脏和外周循环对阿托品所致胆碱能受体阻滞表现出明显的超敏反应，其机制尚不清楚。