Neuropsychopharmacology and Brain Imaging, Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital for Psychiatry Zurich, Zurich, Switzerland.
Nat Rev Neurosci. 2020 Nov;21(11):611-624. doi: 10.1038/s41583-020-0367-2. Epub 2020 Sep 14.
Renewed interest in the use of psychedelics in the treatment of psychiatric disorders warrants a better understanding of the neurobiological mechanisms underlying the effects of these substances. After a hiatus of about 50 years, state-of-the art studies have recently begun to close important knowledge gaps by elucidating the mechanisms of action of psychedelics with regard to their effects on receptor subsystems, systems-level brain activity and connectivity, and cognitive and emotional processing. In addition, functional studies have shown that changes in self-experience, emotional processing and social cognition may contribute to the potential therapeutic effects of psychedelics. These discoveries provide a scientific road map for the investigation and application of psychedelic substances in psychiatry.
对迷幻药在精神疾病治疗中的应用的重新关注，需要更好地了解这些物质作用的神经生物学机制。在中断了大约 50 年之后，最近的先进研究开始通过阐明迷幻药对受体亚系统、大脑活动和连接的系统水平以及认知和情感处理的作用机制来填补重要的知识空白。此外，功能研究表明，自我体验、情绪处理和社会认知的变化可能有助于迷幻药的潜在治疗效果。这些发现为迷幻物质在精神病学中的研究和应用提供了科学路线图。
