Jilin Province Key Laboratory of Functional Organic Molecule Design & Synthesis, Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
Chem Commun (Camb). 2020 Oct 18;56(81):12250-12253. doi: 10.1039/d0cc01060j. Epub 2020 Sep 15.
Enabled by a commercial bisphosphine ligand, the Cu-catalyzed three-component cyclopropene alkenylamination with alkenyl organoboron reagent and hyroxyamine esters proceeds with exceptionally high enantioselectivity to deliver poly-substituted cis-1,2-alkenylcyclopropylamines that contain up to all three stereogenic centers on the cyclopropane.
在商业双膦配体的作用下，铜催化的三组分环丙烯烯基胺化反应与烯基有机硼试剂和羟胺酯反应，具有极高的对映选择性，得到了多取代的顺式-1,2-烯基环丙基胺，其中环丙烷上含有多达三个立体中心。
