Department of Neurosurgery, Aarhus University Hospital, Aarhus, Denmark.
Center for Experimental Neuroscience (CENSE), Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Neuromodulation. 2021 Jan;24(1):76-85. doi: 10.1111/ner.13213. Epub 2020 Sep 14.
Spinal cord stimulation (SCS) is an important treatment modality used to treat chronic neuropathic pain. However, reported success rates of 26%-70% entail an increased focus on patient selection. An area of core interest is psychological evaluation, often using scales such as the Pain Catastrophizing Scale (PCS). The aim of this study was to assess the relation between baseline PCS scores obtained before implantation and SCS outcomes defined as (1) Rating on Patients' Global Impression of Change scale (PGIC), (2) Pain relief on the Numeric Rating Scale (NRS), (3) Cessation of pain medication, and (4) Risk of permanent explantation.
Using records from the Neurizon Neuromodulation Database, we performed a multicenter open cohort study of 259 permanently implanted SCS patients. Follow-up ranged from six months to nine years (median = three years). For each of the defined SCS outcomes, patients were grouped according to their latest follow-up registration. Subsequently, we used a one-way ANOVA and exact t-tests to compare mean baseline PCS scores between groups.
No difference in mean baseline PCS scores was found between PGIC groups. Baseline PCS scores was not associated with the probability of obtaining 30% or 50% pain relief on latest registration. Baseline PCS scores of patients able to cease all usage of tricyclic antidepressants, antiepileptics, or opioids during SCS treatment did not differ from baseline scores of continuous users. We found no association between baseline PCS scores and risk of permanent explantation.
This study did not demonstrate any associations between baseline PCS scores and SCS outcomes.
脊髓刺激(SCS)是治疗慢性神经性疼痛的重要治疗方法。然而,报道的成功率为 26%-70%,这需要更加关注患者的选择。一个核心关注领域是心理评估,通常使用疼痛灾难化量表(PCS)等量表。本研究旨在评估植入前基线 PCS 评分与 SCS 结果之间的关系,SCS 结果定义为(1)患者整体变化评估量表(PGIC)的评分,(2)数字评分量表(NRS)上的疼痛缓解,(3)停止使用止痛药,和(4)永久取出的风险。
我们使用 Neurizon 神经调节数据库中的记录,对 259 例永久性植入 SCS 的患者进行了多中心开放性队列研究。随访时间从六个月到九年(中位数=三年)。对于每个定义的 SCS 结果,根据患者的最新随访登记情况对患者进行分组。然后,我们使用单向方差分析和精确 t 检验比较组间平均基线 PCS 评分。
PGIC 组之间的平均基线 PCS 评分无差异。基线 PCS 评分与获得最新登记时 30%或 50%疼痛缓解的概率无关。在 SCS 治疗期间能够停止使用三环类抗抑郁药、抗癫痫药或阿片类药物的所有使用的患者的基线 PCS 评分与持续使用者的基线评分无差异。我们没有发现基线 PCS 评分与永久取出风险之间的关联。
本研究未显示基线 PCS 评分与 SCS 结果之间存在任何关联。