Kunisawa T, Otsuka J
Department of Applied Biological Science, Faculty of Science and Technology, Science University of Tokyo, Japan.
Protein Seq Data Anal. 1988;1(4):263-7.
A computer search for homologous relationships among Escherichia coli proteins has been carried out with the use of databases. Homologous genes or gene segments thus identified at the amino acid sequence level have a tendency to lie on the genome separated by distances of multiples of 7 min. This relatively regular pattern of gene distribution on the E. coli genome is interpreted as reflecting the early history of multiple genome doublings. Evolutionary advantages of duplications of the total genome are discussed in relation to the acquisition of new multistep pathways such as the Krebs cycle and to the generation of a variety of proteins in existence today.
利用数据库对大肠杆菌蛋白质之间的同源关系进行了计算机搜索。在氨基酸序列水平上如此鉴定出的同源基因或基因片段倾向于位于基因组上，它们之间的距离为7分钟倍数。大肠杆菌基因组上这种相对规则的基因分布模式被解释为反映了多次基因组加倍的早期历史。讨论了全基因组复制的进化优势，涉及到新的多步途径（如三羧酸循环）的获得以及当今存在的各种蛋白质的产生。
