Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.
Int J Dev Biol. 2021;65(4-5-6):345-356. doi: 10.1387/ijdb.200170es.
Molecular oxygen (O), reactive oxygen species (ROS), and associated redox networks are cornerstones of aerobic life. These molecules and networks have gained recognition as fundamental players in mechanisms that regulate the development of multicellular organisms. First, we present a brief review in which we provide a historical description of some relevant discoveries that led to this recognition. We also discuss the fact that, despite its abundance in nature, oxygen is a limiting factor, and its high availability variation impacted the evolution of adaptive mechanisms to guarantee the proper development of diverse species under such extreme environments. Finally, some examples of when oxygen and ROS were identified as relevant for the control of developmental processes are discussed. We take into account not only the current knowledge on animal redox developmental biology, but also briefly discuss potential scenarios on the origin and evolution of redox developmental mechanisms and the importance of the ever-changing environment.
分子氧（O）、活性氧物种（ROS）和相关的氧化还原网络是需氧生命的基石。这些分子和网络已被公认为调节多细胞生物发育的机制中的基本参与者。首先，我们进行了简要回顾，提供了一些相关发现的历史描述，这些发现导致了这种认识。我们还讨论了一个事实，即尽管氧气在自然界中大量存在，但它是一种限制因素，其高可用性变化影响了适应机制的进化，以保证在这种极端环境下多种物种的正常发育。最后，讨论了氧气和 ROS 被确定为控制发育过程的相关因素的一些例子。我们不仅考虑了动物氧化还原发育生物学的现有知识，还简要讨论了氧化还原发育机制的起源和进化的潜在情景以及不断变化的环境的重要性。
