Pandey Gaurav, Ramakrishnan Vibin
Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, 781039, India.
Biophys Rev. 2020 Oct;12(5):1175-1186. doi: 10.1007/s12551-020-00752-y. Epub 2020 Sep 15.
Advancements in medical science have facilitated in extending human lives. The increased life expectancy, though, has come at a cost. The cases of an aging population suffering from degenerative diseases like Alzheimer's disease (AD) are presently at its all-time high. Amyloidosis disorders such as AD are triggered by an abnormal transition of soluble proteins into their highly ordered aggregated forms. The landscape of amyloidosis treatment remains unchanged, and there is no cure for such disorders. However, an increased understanding of the mechanism of amyloid self-assembly has given hope for a possible therapeutic solution. In this review, we will discuss the current state of molecular and non-molecular options for therapeutic intervention of amyloidosis. We highlight the efficacy of non-invasive physical therapies as possible alternatives to their molecular counterparts. Graphical abstract.
医学科学的进步有助于延长人类寿命。然而，预期寿命的增加是有代价的。目前，患有阿尔茨海默病（AD）等退行性疾病的老年人口数量达到了历史最高水平。诸如AD之类的淀粉样变性疾病是由可溶性蛋白质异常转变为高度有序的聚集形式引发的。淀粉样变性疾病的治疗现状没有改变，此类疾病无法治愈。然而，对淀粉样蛋白自组装机制的深入了解为可能的治疗方案带来了希望。在本综述中，我们将讨论淀粉样变性疾病治疗干预的分子和非分子选择的现状。我们强调非侵入性物理疗法作为分子疗法替代方案的有效性。图形摘要。
