Department of Obstetrics and Gynaecology, APHM, Nord Hospital, Marseille, France.
EA3279, CEReSS, Health Service Research and Quality of Life Centre, Aix-Marseille University, Marseille, France.
BJOG. 2021 Feb;128(3):594-602. doi: 10.1111/1471-0528.16499. Epub 2020 Oct 8.
To evaluate whether caesarean delivery before 26 weeks of gestation was associated with symptoms of depression and anxiety in mothers in comparison with deliveries between 26 and 34 weeks.
Prospective national population-based EPIPAGE-2 cohort study.
268 neonatology departments in France, March to December 2011.
Mothers who delivered between 22 and 34 weeks and whose self-reported symptoms of depression (Center for Epidemiologic Studies Depression Scale: CES-D) and anxiety (State-Trait Anxiety Inventory: STAI) were assessed at the moment of neonatal discharge.
The association of caesarean delivery before 26 weeks with severe symptoms of depression (CES-D ≥16) and anxiety (STAI ≥45) was assessed by weighted and design-based log-linear regression model.
Severe symptoms of depression and anxiety in mothers of preterm infants.
Among the 2270 women completing CES-D and STAI questionnaires at the time of neonatal discharge, severe symptoms of depression occurred in 25 (65.8%) women having a caesarean before 26 weeks versus in 748 (50.6%) women having a caesarean after 26 weeks. Caesarean delivery before 26 weeks was associated with severe symptoms of depression compared with caesarean delivery after 26 weeks (adjusted relative risk [aRR] 1.42, 95% CI 1.12-1.81) adjusted to neonatal birthweight and severe neonatal morbidity among other factors. There was no evidence of an association between mode of delivery and symptoms of anxiety.
Mothers having a caesarean delivery before 26 weeks' gestation are at high risk of symptoms of depression and may benefit from specific preventive care.
Mothers having caesarean delivery before 26 weeks' gestation are at high risk of symptoms of depression.
评估相较于 26-34 孕周分娩，26 孕周前剖宫产与母亲抑郁和焦虑症状的相关性。
前瞻性全国基于人群的 EPIPAGE-2 队列研究。
法国 268 个新生儿科病房，2011 年 3 月至 12 月。
在 22-34 孕周分娩且在新生儿出院时自评抑郁症状（流行病学研究中心抑郁量表：CES-D）和焦虑症状（状态特质焦虑量表：STAI）的母亲。
通过加权和基于设计的对数线性回归模型评估 26 孕周前剖宫产与严重抑郁症状（CES-D≥16）和焦虑症状（STAI≥45）的相关性。
早产儿母亲的严重抑郁和焦虑症状。
在 2270 名在新生儿出院时完成 CES-D 和 STAI 问卷的女性中，26 孕周前剖宫产的 25 名（65.8%）女性出现严重抑郁症状，而 26 孕周后剖宫产的 748 名（50.6%）女性出现严重抑郁症状。相较于 26 孕周后剖宫产，26 孕周前剖宫产与严重抑郁症状相关（调整后的相对风险 [aRR] 1.42，95%CI 1.12-1.81），在调整新生儿出生体重和其他严重新生儿发病率等因素后。在分娩方式与焦虑症状之间没有证据表明存在相关性。
26 孕周前剖宫产的母亲有发生抑郁症状的高风险，可能需要接受特定的预防保健。
26 孕周前剖宫产的母亲有发生抑郁症状的高风险。
