Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario "A. Gemelli" I.R.C.C.S, Rome, Italy.
Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario "A. Gemelli" I.R.C.C.S, Rome, Italy.
Scand J Immunol. 2021 Mar;93(3):e12977. doi: 10.1111/sji.12977. Epub 2020 Sep 26.
In the natural history of SARS-CoV-2 infection, liver injury is frequent but quite mild and it is defined as any liver damage occurring during disease progression and treatment of infection in patients with or without pre-existing liver diseases. The underlying mechanisms for hepatic injury in patients with COVID-19 are still unclear but the liver damage in SARS-CoV-2 infection seems to be directly caused by virus-induced cytopathic effects. In this review, we will summarize all data of updated literature, regarding the relationship between SARS-CoV-2 infection, acute response and liver involvement. An overview will be given on liver injury, liver transplant and the possible consequences of COVID-19 in patients with pre-existing liver diseases.
在 SARS-CoV-2 感染的自然史中，肝损伤很常见，但相当轻微，它被定义为在有或没有潜在肝病的患者中，在疾病进展和治疗感染过程中发生的任何肝损伤。COVID-19 患者肝损伤的潜在机制尚不清楚，但 SARS-CoV-2 感染中的肝损伤似乎是由病毒诱导的细胞病变作用直接引起的。在这篇综述中，我们将总结关于 SARS-CoV-2 感染、急性反应和肝脏受累之间关系的最新文献中的所有数据。将概述肝损伤、肝移植以及 COVID-19 在患有潜在肝脏疾病的患者中的可能后果。
