同病异源：不同细胞起源塑造胶质母细胞瘤的分子特征和治疗反应。

Same Script, Different Cast: Different Cell Origins Shape Molecular Features and Therapeutic Response in Glioblastoma.

机构信息

Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA.

Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA; Moores Cancer Center, University of California at San Diego, La Jolla, CA, USA; Department of Pathology, University of California at San Diego, La Jolla, CA, USA; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.

出版信息

Cancer Cell. 2020 Sep 14;38(3):311-313. doi: 10.1016/j.ccell.2020.08.012.

DOI:10.1016/j.ccell.2020.08.012

PMID:32931740

Abstract

Glioblastoma is heterogeneous in the molecular subtypes based on transcriptomic classification. In this issue of Cancer Cell, Wang et al. define a cell-lineage-based stratification model for glioblastoma, highlighting how the cell of origin generates distinct molecular landscapes and therapeutic vulnerabilities from identical driver mutations.

摘要

胶质母细胞瘤在基于转录组分类的分子亚型上存在异质性。在本期《癌细胞》中，Wang 等人定义了一种基于细胞谱系的胶质母细胞瘤分层模型，强调了起源细胞如何从相同的驱动突变产生不同的分子景观和治疗弱点。