通过谱系追踪记录 EMT 活动在转移过程中。
Recording EMT Activity by Lineage Tracing during Metastasis.
机构信息
Laboratory of Stem Cells and Cancer, WELBIO, Université Libre de Bruxelles (ULB), 808 route de Lennik, Bat GE, G2 4.205, 1070 Bruxelles, Belgium.
Laboratory of Stem Cells and Cancer, WELBIO, Université Libre de Bruxelles (ULB), 808 route de Lennik, Bat GE, G2 4.205, 1070 Bruxelles, Belgium.
出版信息
Dev Cell. 2020 Sep 14;54(5):567-569. doi: 10.1016/j.devcel.2020.07.011.
In this issue of Developmental Cell, Li et al. develop a novel lineage tracing system to record EMT activity during lung metastasis of mammary tumors. Using EMT-tracer mouse models, they reveal that N-cadherin is transiently expressed by most metastasis-initiating cells and demonstrate its functional importance during the metastatic cascade.
本期《发育细胞》中，李等人开发了一种新的谱系追踪系统，以记录乳腺肿瘤肺转移过程中的 EMT 活性。他们利用 EMT 示踪小鼠模型，揭示了大多数起始转移细胞短暂表达 N-钙黏蛋白，并证明了其在转移级联反应过程中的功能重要性。
Zotero 插件