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通过谱系追踪记录 EMT 活动在转移过程中。

Recording EMT Activity by Lineage Tracing during Metastasis.

机构信息

Laboratory of Stem Cells and Cancer, WELBIO, Université Libre de Bruxelles (ULB), 808 route de Lennik, Bat GE, G2 4.205, 1070 Bruxelles, Belgium.

Laboratory of Stem Cells and Cancer, WELBIO, Université Libre de Bruxelles (ULB), 808 route de Lennik, Bat GE, G2 4.205, 1070 Bruxelles, Belgium.

出版信息

Dev Cell. 2020 Sep 14;54(5):567-569. doi: 10.1016/j.devcel.2020.07.011.

DOI:10.1016/j.devcel.2020.07.011
PMID:32931747
Abstract

In this issue of Developmental Cell, Li et al. develop a novel lineage tracing system to record EMT activity during lung metastasis of mammary tumors. Using EMT-tracer mouse models, they reveal that N-cadherin is transiently expressed by most metastasis-initiating cells and demonstrate its functional importance during the metastatic cascade.

摘要

本期《发育细胞》中，李等人开发了一种新的谱系追踪系统，以记录乳腺肿瘤肺转移过程中的 EMT 活性。他们利用 EMT 示踪小鼠模型，揭示了大多数起始转移细胞短暂表达 N-钙黏蛋白，并证明了其在转移级联反应过程中的功能重要性。

相似文献

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Recording EMT Activity by Lineage Tracing during Metastasis.通过谱系追踪记录 EMT 活动在转移过程中。
Dev Cell. 2020 Sep 14;54(5):567-569. doi: 10.1016/j.devcel.2020.07.011.
2
The functional activity of E-cadherin controls tumor cell metastasis at multiple steps.E-钙黏蛋白的功能活性控制着肿瘤细胞在多个步骤中的转移。
Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5931-5937. doi: 10.1073/pnas.1918167117. Epub 2020 Mar 3.
3
Inhibition of Epithelial-Mesenchymal Transition and Metastasis by Combined TGFbeta Knockdown and Metformin Treatment in a Canine Mammary Cancer Xenograft Model.在犬乳腺肿瘤异种移植模型中，联合敲低转化生长因子β（TGFβ）与二甲双胍治疗对上皮-间质转化及转移的抑制作用
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Epithelial requirement for in vitro proliferation and xenograft growth and metastasis of MDA-MB-468 human breast cancer cells: oncogenic rather than tumor-suppressive role of E-cadherin.MDA-MB-468人乳腺癌细胞体外增殖、异种移植生长及转移的上皮细胞需求：E-钙黏蛋白的致癌而非抑癌作用
Breast Cancer Res. 2017 Jul 27;19(1):86. doi: 10.1186/s13058-017-0880-z.
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Epithelial-mesenchymal plasticity is a decisive feature for the metastatic outgrowth of disseminated WAP-T mouse mammary carcinoma cells.上皮-间质可塑性是播散的WAP-T小鼠乳腺癌细胞转移生长的决定性特征。
BMC Cancer. 2015 Mar 26;15:178. doi: 10.1186/s12885-015-1165-5.
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E-cadherin re-expression shows in vivo evidence for mesenchymal to epithelial transition in clonal metastatic breast tumor cells.E-钙黏蛋白的重新表达显示了克隆性转移性乳腺癌细胞中从间充质到上皮转变的体内证据。
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Breast tumor cell-specific knockout of inhibits cancer cell plasticity, dissemination, and lung metastasis in mice.乳腺肿瘤细胞特异性敲除 可抑制小鼠癌细胞可塑性、扩散和肺转移。
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Transglutaminase-2 induces N-cadherin expression in TGF-β1-induced epithelial mesenchymal transition via c-Jun-N-terminal kinase activation by protein phosphatase 2A down-regulation.转谷氨酰胺酶 2 通过下调蛋白磷酸酶 2A 激活 c-Jun-N 端激酶诱导 TGF-β1 诱导的上皮间质转化中 N 钙粘蛋白的表达。
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Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity.上皮与间充质状态之间的可塑性使上皮-间质转化与增强转移的干细胞能力脱钩。
Cell Rep. 2016 Mar 15;14(10):2281-8. doi: 10.1016/j.celrep.2016.02.034. Epub 2016 Mar 3.
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Fsp1-Mediated Lineage Tracing Fails to Detect the Majority of Disseminating Cells Undergoing EMT.Fsp1 介导的谱系追踪未能检测到大多数经历 EMT 的播散细胞。
Cell Rep. 2019 Nov 26;29(9):2565-2569.e3. doi: 10.1016/j.celrep.2019.10.107.

引用本文的文献

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Be like water, my cells: cell plasticity and the art of transformation.我的细胞们，如水般流淌：细胞可塑性与转变的艺术。
Front Cell Dev Biol. 2023 Oct 11;11:1272730. doi: 10.3389/fcell.2023.1272730. eCollection 2023.
2
ING5 overexpression upregulates miR-34c-5p/Snail1 to inhibit EMT and invasion of lung cancer cells.ING5 过表达上调 miR-34c-5p/Snail1 抑制肺癌细胞 EMT 和侵袭。
Acta Biochim Biophys Sin (Shanghai). 2023 May 30;55(5):809-817. doi: 10.3724/abbs.2023074.
3
JP1 normalizes tumor vasculature to suppress metastasis and facilitate drug delivery by inhibiting IL-8.
JP1 通过抑制白细胞介素-8（IL-8）使肿瘤血管正常化，以抑制转移并促进药物输送。
JCI Insight. 2023 Jun 22;8(12):e161675. doi: 10.1172/jci.insight.161675.
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Perfect duet: Dual recombinases improve genetic resolution.完美二重奏：双重组酶提高遗传分辨率。
Cell Prolif. 2023 May;56(5):e13446. doi: 10.1111/cpr.13446. Epub 2023 Apr 14.
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Effect of ZEB1 Associated with microRNAs on Tumor Stem Cells in Head and Neck Cancer.ZEB1 相关的 microRNAs 对头颈部癌细胞肿瘤干细胞的影响。
Int J Mol Sci. 2023 Mar 21;24(6):5916. doi: 10.3390/ijms24065916.
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A novel epithelial-mesenchymal transition (EMT)-related gene signature of predictive value for the survival outcomes in lung adenocarcinoma.一种对肺腺癌生存结局具有预测价值的新型上皮-间质转化（EMT）相关基因特征。
Front Oncol. 2022 Sep 15;12:974614. doi: 10.3389/fonc.2022.974614. eCollection 2022.
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Deciphering functional tumor states at single-cell resolution.解析单细胞分辨率下的功能性肿瘤状态。
EMBO J. 2022 Dec 17;41(2):e109221. doi: 10.15252/embj.2021109221. Epub 2021 Dec 17.
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Dual recombinases-based genetic lineage tracing for stem cell research with enhanced precision.基于双重组酶的遗传谱系示踪技术，可提高干细胞研究的精确性。
Sci China Life Sci. 2021 Dec;64(12):2060-2072. doi: 10.1007/s11427-020-1889-9. Epub 2021 Apr 9.