Dally-like 不像 Dally 那样有助于无翅散布。

Dally-like Is Unlike Dally in Assisting Wingless Spread.

机构信息

Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Waldeyerstrasse 15, 48149 Münster, Germany.

Tissue and Organ Homeostasis, Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Nicolás Cabrera 1, Universidad Autónoma de Madrid, 28049 Madrid, Spain.

出版信息

Dev Cell. 2020 Sep 14;54(5):572-573. doi: 10.1016/j.devcel.2020.08.011.

DOI:10.1016/j.devcel.2020.08.011

PMID:32931749

Abstract

Lipidated morphogens can spread within tissues to regulate cell fate during development or tissue repair. How these insoluble molecules reach distant target cells remains unclear. Reporting in Nature, McGough et al. (2020) reveal the secret of how the cell-surface proteoglycan Dally-like-protein (Dlp) promotes long-range signaling of the palmitoylated morphogen Wingless.

摘要

脂化形态发生素可在组织内扩散，以在发育或组织修复过程中调节细胞命运。这些不溶性分子如何到达远处的靶细胞尚不清楚。在《自然》杂志上，McGough 等人（2020 年）揭示了细胞表面蛋白聚糖 Dally-like-protein（Dlp）如何促进棕榈酰化形态发生素 Wingless 的长距离信号传递的秘密。