Ervin M G
Department of Obstetrics and Gynecology, University of California, Los Angeles School of Medicine, Harbor-UCLA Medical Center, Torrance 90509.
Semin Perinatol. 1988 Apr;12(2):134-42.
Not many years ago, the fetus was perceived to exert little impact on amniotic fluid homeostasis. It is now clear that the fetus plays an integral role in modulating fluid flux between the maternal, fetal, and amniotic fluid compartments. Moreover, fetal AVP secretion and the associated renal and cardiovascular responses represent important aspects of the potential to adapt to changes in the intrauterine environment. Although the physiologic significance of the increased AVP secretion observed in response to labor and delivery remain speculative, AVP regulation also is an essential aspect of neonatal adaptation. Still, many questions remain regarding both the regulation of fetal and neonatal fluid dynamics and the ontogeny of AVP receptor systems.
就在几年前，人们还认为胎儿对羊水内环境稳定的影响很小。现在很清楚，胎儿在调节母体、胎儿和羊水腔室之间的液体通量方面起着不可或缺的作用。此外，胎儿抗利尿激素（AVP）的分泌以及相关的肾脏和心血管反应是适应子宫内环境变化潜力的重要方面。尽管因分娩而观察到的抗利尿激素分泌增加的生理意义仍具有推测性，但抗利尿激素的调节也是新生儿适应的一个重要方面。然而，关于胎儿和新生儿液体动力学的调节以及抗利尿激素受体系统的个体发生，仍有许多问题存在。
