School of Pharmaceutical Sciences, São Paulo State University, Araraquara, São Paulo, 14800-903, Brazil.
Laboratory of Biopolymers and Biomaterials, University of Araraquara, Araraquara, São Paulo, 14801-320, Brazil.
Carbohydr Polym. 2020 Dec 1;249:116838. doi: 10.1016/j.carbpol.2020.116838. Epub 2020 Aug 11.
Defibrillation of bacterial cellulose by ultra-refining was efficient to release nanofibers (BCNF) which were spray dried with the matrices formers mannitol (MN), maltodextrin or hydroxypropylmethylcellulose. The best microsystem comprised the association of BCNF and MN, so the selected microparticles were loaded with diclofenac sodium or caffeine. Depending on the proportion of BCNF, the nanofibers collapse promoted by spray drying can occur onto surface or into microparticles core, leading to different release behaviors. Samples showed pH-dependent drug release, so the microsystem developed with the lowest BCNF concentration showed important trend to gastroresistance. Caffeine was spray dried as a free drug and for this reason it was devoid of any control over release rates. The set of results showed BCNF can be considered an interesting and potential pharmaceutical excipient for lipophilic drugs. Beyond that, BCNF association with MN can lead to novel enteric drug delivery systems based on natural polymers.
超声处理可使细菌纤维素解纤，释放出纳米纤维（BCNF），然后可将其与甘露醇（MN）、麦芽糊精或羟丙基甲基纤维素等基质成型剂一起喷雾干燥。由 BCNF 和 MN 组成的最佳微系统，所以选择的微粒载有双氯芬酸钠或咖啡因。根据 BCNF 的比例，喷雾干燥时纳米纤维的坍塌可能发生在表面或微球核心，导致不同的释放行为。样品表现出 pH 依赖性药物释放，因此用最低 BCNF 浓度开发的微系统显示出重要的抗胃作用趋势。咖啡因作为游离药物进行喷雾干燥，因此它对释放速率没有任何控制。这一系列结果表明，BCNF 可被视为一种用于脂溶性药物的有趣且有潜力的药用辅料。除此之外，BCNF 与 MN 结合可以形成基于天然聚合物的新型肠内药物传递系统。
