Massachusetts General Hospital, Department of Surgery, Division of Surgical Oncology, USA; Brigham and Women's Hospital, Department of Surgery, Division of Endocrine Surgery, USA; Rush University Medical Center, Department of Surgery, Division of Surgical Oncology, USA.
Medical College of Wisconsin, Department of Surgery, Division of Endocrine Surgery, USA.
Am J Surg. 2021 Feb;221(2):448-454. doi: 10.1016/j.amjsurg.2020.07.032. Epub 2020 Aug 21.
Patients with low-risk-PTC who undergo thyroid lobectomy (TL) have comparable disease-specific survival with lower morbidity than total thyroidectomy (TT). We aim to describe the surgical management of low-risk-PTC using the Collaborative Endocrine Surgery Quality Improvement Program (CESQIP).
CESQIP thyroidectomies of PTC tumors <4 cm were analyzed from 2014 to 2019 (n = 740). Postoperative outcomes were compared. Subgroup analysis examined temporal and institutional trends, and stratified for tumor size. Statistics utilized t-test, ANOVA, and Chi-squared.
TT patients had greater hypoparathyroidism, operative time, and length-of-stay (all p < 0.001). Incidence of TL decreased with increasing tumor size (24.2% for <1 cm, 15.8% for 1-2 cm, 6.1% for 2-4 cm). TL rates increased from 2.0% in 2014 to 21.2% in 2018-19. Completion thyroidectomy was recommended in 12.0% of TL subjects. There was significant variation in TL rate by institution (p < .001).
For low-risk-PTC, TT remained the most commonly utilized operation. TL rates increased following release of the new ATA guidelines. TT was associated with higher perioperative morbidity. Further insight is needed to understand factors influencing operative approach.
与全甲状腺切除术(TT)相比,接受甲状腺叶切除术(TL)的低危-PTC 患者具有相当的疾病特异性存活率和更低的发病率。我们旨在使用协作内分泌手术质量改进计划(CESQIP)描述低危-PTC 的手术管理。
对 2014 年至 2019 年期间(n=740)的 CESQIP 甲状腺切除术的 PTC 肿瘤<4cm 进行了分析。比较了术后结果。亚组分析检查了时间和机构趋势,并按肿瘤大小分层。统计学分析采用 t 检验、方差分析和卡方检验。
TT 患者甲状旁腺功能减退症、手术时间和住院时间更长(均 p<0.001)。TL 发生率随肿瘤大小的增加而降低(<1cm 为 24.2%,1-2cm 为 15.8%,2-4cm 为 6.1%)。TL 率从 2014 年的 2.0%增加到 2018-19 年的 21.2%。TL 患者中有 12.0%建议行补充甲状腺切除术。不同机构 TL 率存在显著差异(p<0.001)。
对于低危-PTC,TT 仍然是最常用的手术。新 ATA 指南发布后,TL 率有所增加。TT 与较高的围手术期发病率相关。需要进一步深入了解影响手术方法的因素。