Munch Elisabeth Lobben, Skurtveit Svetlana, Handal Marte, Skovlund Eva
Norwegian University of Science and Technology, Medical Studies, Trondheim, Norway.
Norwegian Institute of Public Health, Oslo, Norway.
Nordisk Alkohol Nark. 2020 Feb;37(1):43-53. doi: 10.1177/1455072519879564. Epub 2019 Nov 16.
Paternal lifestyle during sperm development can have an impact on foetal development. This study surveys demographic characteristics and lifestyle factors among expectant fathers who reported use of cannabis and cocaine in the six-month period before conception. We also study the associations between mothers' and fathers' use of cannabis and cocaine.
This is a cross-sectional study from the Norwegian Mother and Child Cohort Study (MoBa) using self-reported data on demographic variables and cannabis and cocaine use six months before conception. Associations were assessed using logistic regression and chi-square tests.
A strong association was found between use of cannabis and cocaine and lifestyle habits such as alcohol and cigarette use. Alcohol consumption four or more times a week gave an adjusted odds ratio (a) of 9.7 (95% CI 7.2-13.0) for cannabis and an a 21.6 (95% CI 11.5-40.3) for cocaine. There was also a strong association between maternal and paternal use of cannabis and cocaine.
Use of cannabis and cocaine close to pregnancy seems to be closely linked to other risk factors, and further studies on how paternal drug use affects the foetus are warranted. The strong association between maternal and paternal use of cannabis and cocaine may be used to inform healthcare workers to make good risk assessments.
精子发育期间父亲的生活方式会对胎儿发育产生影响。本研究调查了在受孕前六个月报告使用大麻和可卡因的准父亲的人口统计学特征和生活方式因素。我们还研究了母亲和父亲使用大麻和可卡因之间的关联。
这是一项来自挪威母婴队列研究(MoBa)的横断面研究,使用关于人口统计学变量以及受孕前六个月大麻和可卡因使用情况的自我报告数据。使用逻辑回归和卡方检验评估关联。
发现使用大麻和可卡因与饮酒和吸烟等生活方式习惯之间存在强烈关联。每周饮酒四次或更多次,大麻的调整优势比(a)为9.7(95%可信区间7.2 - 13.0),可卡因为21.6(95%可信区间11.5 - 40.3)。母亲和父亲使用大麻和可卡因之间也存在强烈关联。
接近孕期使用大麻和可卡因似乎与其他风险因素密切相关,有必要进一步研究父亲药物使用如何影响胎儿。母亲和父亲使用大麻和可卡因之间的强烈关联可用于指导医护人员进行良好的风险评估。