Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
Synapse. 2012 Oct;66(10):902-8. doi: 10.1002/syn.21582. Epub 2012 Jul 27.
Despite the increased prevalence of cocaine use and abuse in males when compared with females, possible effects of paternal cocaine exposure on biobehavioral development have received little attention. We therefore exposed male mice to cocaine (20 mg/kg, i.p.) or vehicle for 10 weeks and then used those mice as sires. We then behaviorally phenotyped the F1 offspring to assess the consequences of paternal cocaine exposure on brain function. We report the presence of a subtle but significant increase in immobility in the tail suspension test, a measure of behavioral depression, following paternal cocaine. Body weight was also significantly decreased in paternal cocaine-exposed offspring. Other aspects of neurobehavioral function, including locomotor activity, anxiety, and learning and memory, were not affected by paternal cocaine history. These data suggest alterations in brain systems and/or circuitry underlying mood regulation in the offspring of cocaine-using fathers. Synapse 2012. © 2012 Wiley Periodicals, Inc.
尽管与女性相比，男性可卡因使用和滥用的情况更为普遍，但父代可卡因暴露对生物行为发育的可能影响却很少受到关注。因此，我们让雄性老鼠接受可卡因（20mg/kg，腹腔注射）或载体 10 周，然后让这些老鼠作为父鼠。然后，我们对 F1 后代进行行为表型分析，以评估父代可卡因暴露对大脑功能的影响。我们报告说，在尾巴悬挂测试中，行为抑郁的一种衡量标准，即不动性，在雄性可卡因暴露后出现了轻微但显著的增加。父代可卡因暴露的后代的体重也显著下降。神经行为功能的其他方面，包括运动活动、焦虑和学习记忆，不受父代可卡因史的影响。这些数据表明，在使用可卡因的父亲的后代中，与情绪调节相关的大脑系统和/或电路发生了改变。Synapse 2012。©2012 Wiley Periodicals, Inc.
