Peng Hao, Wang Yufeng, Shen Lingyue, Zhou Guoyu
Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, Shanghai 200011, P.R. China.
Department of Laser and Aesthetic Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, Shanghai 200011, P.R. China.
Exp Ther Med. 2020 Nov;20(5):6. doi: 10.3892/etm.2020.9134. Epub 2020 Aug 25.
Reflectance confocal microscopy (RCM) is a non-invasive tool that provides real-time microscopic images and relatively high-resolution tissue images. This technique provides a link between clinical examination and histopathology. RCM has been used to detect skin diseases and has also recently been applied to diseases of the oral mucosa. The present study aimed to explore the features of oral lichen planus (OLP) using RCM. A total of 47 patients with OLP exhibiting a reticular pattern, were included in the present study. The lesion sites and healthy adjacent sites were examined using RCM, with the lesion being histopathologically confirmed after RCM examination. The confocal images were reviewed, and the features were described. Sensitivity and specificity analysis of the RCM features was also performed. RCM examination presented parakeratosis, acanthosis and connective tissue papillae disappearance, with the presence of large melanocytes and roundish inflammatory cell infiltration, as well as dilated vessels in the lesion tissue. The sensitivity and specificity of OLP for dorsal tongue lesions were not as satisfactory as those on other sites. The results implied that RCM may be a promising technique to detect OLP non-invasively .
反射共聚焦显微镜（RCM）是一种非侵入性工具，可提供实时微观图像和相对高分辨率的组织图像。该技术在临床检查和组织病理学之间建立了联系。RCM已被用于检测皮肤疾病，最近也被应用于口腔黏膜疾病。本研究旨在利用RCM探索口腔扁平苔藓（OLP）的特征。本研究共纳入47例表现为网状图案的OLP患者。使用RCM检查病变部位和相邻健康部位，在RCM检查后对病变进行组织病理学确认。回顾共聚焦图像并描述其特征。还对RCM特征进行了敏感性和特异性分析。RCM检查显示病变组织出现角化不全、棘层肥厚和结缔组织乳头消失，伴有大的黑素细胞和圆形炎性细胞浸润以及血管扩张。OLP在舌背病变的敏感性和特异性不如在其他部位。结果表明，RCM可能是一种有前景的非侵入性检测OLP的技术。
