Zhuo Siqi, Zhang Xiaoyue, Luo Huan, Wang Xuehua, Ji Yibing
Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, 210009, China.
Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, Nanjing, 210009, China.
Macromol Rapid Commun. 2020 Oct;41(20):e2000404. doi: 10.1002/marc.202000404. Epub 2020 Sep 16.
Covalent organic frameworks (COFs) made their debut in 2005 and caused enthusiastic attention because of their ordered, crystalline structure. They are constructed with pure organic building blocks that are linked together by robust covalent linkages. COFs are applied in numerous fields due to their large surface area, architecture and chemistry stabilities, functional pore walls, and tunable frameworks. Incorporating COFs with chiral compounds can build chiral COFs (CCOFs), which have exhibited significant advantages in the chiral chemistry field. This review focuses on the applications of COFs for chiral catalysis, chiral separation, and chiral sensoring up to now. Furthermore, the synthesis and design strategies of CCOFs are also discussed in this article, since the COFs used in chiral chemistry are generally CCOFs. There also sums up the benefits and defects of COFs used in the chiral field and outlines future opportunities. The studies described in this review demonstrate not only the advantages of COFs in practical use but also novel solutions for the problems in the chirality area.
共价有机框架（COFs）于2005年首次亮相，因其有序的晶体结构而引起了广泛关注。它们由纯有机结构单元构建而成，通过强大的共价键连接在一起。由于其大表面积、结构和化学稳定性、功能性孔壁以及可调节的框架，COFs在众多领域得到应用。将COFs与手性化合物结合可以构建手性COFs（CCOFs），其在手性化学领域已展现出显著优势。本综述重点介绍了迄今为止COFs在手性催化、手性分离和手性传感方面的应用。此外，本文还讨论了CCOFs的合成和设计策略，因为在手性化学中使用的COFs通常是CCOFs。同时总结了手性领域中COFs的优点和缺点，并概述了未来的机遇。本综述中描述的研究不仅展示了COFs在实际应用中的优势，还为手性领域的问题提供了新的解决方案。
