病肝歧路分，单核细胞双行。
Two Roads Diverge in the Sick Liver, Monocytes Travel Both.
机构信息
The Research Center for Digestive Tract and Liver Diseases, Tel-Aviv Sourasky Medical Center and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 64239, Israel.
The Research Center for Digestive Tract and Liver Diseases, Tel-Aviv Sourasky Medical Center and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 64239, Israel; Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.
出版信息
Immunity. 2020 Sep 15;53(3):479-481. doi: 10.1016/j.immuni.2020.08.006.
Liver macrophages play critical roles in the pathogenesis of non-alcoholic steatohepatitis (NASH). In this issue of Immunity, Tran et al. and Remmerie et al. reveal that Ly6C monocytes in NASH replace dying resident Kupffer cells, while concomitantly are differentiating into distinct lipid associated macrophages.
肝巨噬细胞在非酒精性脂肪性肝炎（NASH）的发病机制中起着关键作用。在本期《免疫》杂志上，Tran 等人和 Remmerie 等人揭示，NASH 中的 Ly6C 单核细胞替代死亡的固有库普弗细胞，同时分化为不同的与脂质相关的巨噬细胞。
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