Swedish Liver Care Network and Organ Care Research, Swedish Medical Center, 1124 Columbia Street, Suite 600, Seattle, WA 98104, USA.
Swedish Liver Care Network and Organ Care Research, Swedish Medical Center, 1124 Columbia Street, Suite 600, Seattle, WA 98104, USA.
Clin Liver Dis. 2018 Feb;22(1):23-37. doi: 10.1016/j.cld.2017.08.007. Epub 2017 Oct 18.
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver disorders ranging from hepatic steatosis to nonalcoholic steatohepatitis (NASH) and ultimately may lead to cirrhosis. Hepatic steatosis or fatty liver is defined as increased accumulation of lipids in hepatocytes and results from increased production or reduced clearance of hepatic triglycerides or fatty acids. Fatty liver can progress to NASH in a significant proportion of subjects. NASH is a necroinflammatory liver disease governed by multiple pathways that are not completely elucidated. This review describes the main mechanisms that have been reported to contribute to the pathophysiology of NAFLD and NASH.
非酒精性脂肪性肝病（NAFLD）涵盖了一系列肝脏疾病，从肝脂肪变性到非酒精性脂肪性肝炎（NASH），最终可能导致肝硬化。肝脂肪变性或脂肪肝定义为肝细胞内脂质堆积增加，这是由于肝甘油三酯或脂肪酸的产生增加或清除减少所致。在很大一部分患者中，脂肪肝可进展为 NASH。NASH 是一种由多种尚未完全阐明的途径调控的坏死性炎症性肝病。本综述描述了据报道有助于 NAFLD 和 NASH 发病机制的主要机制。
