Aurnhammer W, Konietzko N, Matthys H
Respiration. 1977;34(2):92-9. doi: 10.1159/000193781.
In a double-blind cross-over study the effect of two secretolytic agents on the mucociliary clearance was tested in 8 patients with mild chronic obstructive bronchitis. Clearance was assessed from the removal rate of previously inhaled sulfur colloid particles, tagged with 99Tcm. For the interpreatation of the results, obtained by this method, it is essential to take into account the pattern of particle deposition. For example there was a faster clearance under placebo compared to the secretolytic drugs because of a more central deposition. To overcome this problem different approaches were therefore tested. The following constellations proved to be useful in assessing the effect of secretolytic drugs: (1) change in deposition patter; (2) clearance rate, if no change in deposition takes place; (3) clearance rate from a peripheral area of the lung. An attempt to apply a simple three compartment model proved to be unpracticable probably becuase of the complexity of the mechanism involved. One of these mechanisms could be a reversal in mucus transport, observed at least in one patient, a finding which might be of pathophysiological relevance.
在一项双盲交叉研究中，对8例轻度慢性阻塞性支气管炎患者测试了两种促分泌剂对黏液纤毛清除功能的影响。通过测量先前吸入的用99锝标记的硫胶体颗粒的清除率来评估清除功能。对于用这种方法获得的结果进行解释时，必须考虑颗粒沉积的模式。例如，由于颗粒更集中于中央部位沉积，与促分泌剂相比，安慰剂组的清除速度更快。因此，为克服这一问题，测试了不同的方法。以下几种组合被证明对评估促分泌剂的效果有用：（1）沉积模式的改变；（2）如果沉积没有变化，则为清除率；（3）肺外周区域的清除率。应用简单的三室模型的尝试被证明是不可行的，这可能是由于所涉及机制的复杂性。这些机制之一可能是黏液转运的逆转，至少在1例患者中观察到这一现象，这一发现可能具有病理生理学意义。
