Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Int J Mol Sci. 2020 Sep 14;21(18):6727. doi: 10.3390/ijms21186727.
Glycosylation plays critical roles in various biological processes and is closely related to diseases. Deciphering the glycocode in diverse cells and tissues offers opportunities to develop new disease biomarkers and more effective recombinant therapeutics. In the past few decades, with the development of glycobiology, glycomics, and glycoproteomics technologies, a large amount of glycoscience data has been generated. Subsequently, a number of glycobiology databases covering glycan structure, the glycosylation sites, the protein scaffolds, and related glycogenes have been developed to store, analyze, and integrate these data. However, these databases and tools are not well known or widely used by the public, including clinicians and other researchers who are not in the field of glycobiology, but are interested in glycoproteins. In this study, the representative databases of glycan structure, glycoprotein, glycan-protein interactions, glycogenes, and the newly developed bioinformatic tools and integrated portal for glycoproteomics are reviewed. We hope this overview could assist readers in searching for information on glycoproteins of interest, and promote further clinical application of glycobiology.
糖基化在各种生物过程中起着关键作用，与疾病密切相关。解析不同细胞和组织中的糖码为开发新的疾病生物标志物和更有效的重组治疗方法提供了机会。在过去的几十年中，随着糖生物学、糖组学和糖蛋白质组学技术的发展，产生了大量的糖科学数据。随后，开发了许多糖生物学数据库，涵盖聚糖结构、糖基化位点、蛋白质支架和相关糖基因，以存储、分析和整合这些数据。然而，这些数据库和工具不为公众所熟知，也未被广泛使用，包括临床医生和其他非糖生物学领域但对糖蛋白感兴趣的研究人员。在本研究中，我们回顾了糖链结构、糖蛋白、糖蛋白相互作用、糖基因的代表性数据库，以及新开发的糖蛋白质组学生物信息学工具和综合门户。我们希望这篇综述可以帮助读者搜索感兴趣的糖蛋白信息，并促进糖生物学的进一步临床应用。
