Gu Yichao, Sun Xueliang, Wan Bin, Lu Zhuoer, Zhang Yanghui
School of Chemical Science and Engineering, Shanghai Key Laboratory of Chemical Assessment and Sustainability, Tongji University, 1239 Siping Road, Shanghai 200092, China.
Chem Commun (Camb). 2020 Sep 17;56(74):10942-10945. doi: 10.1039/d0cc04602g.
A palladium-catalyzed cross-coupling reaction of aryl halides with 2-chlorobenzoic acids has been developed. The reaction forms C(sp3), C(sp2)-palladacycles through C(sp3)-H activation. The palladacycles react with 2-chlorobenzoic acids through two successive C-C cross-couplings, and two C-C bonds are formed with high chemoselectivity. The reaction provides an innovative method for the synthesis of 9,10-dihydrophenanthrenes.
已开发出一种钯催化的芳基卤化物与2-氯苯甲酸的交叉偶联反应。该反应通过C(sp³)-H活化形成C(sp³)，C(sp²)-钯环。钯环通过两个连续的C-C交叉偶联与2-氯苯甲酸反应，并以高化学选择性形成两个C-C键。该反应为9,10-二氢菲的合成提供了一种创新方法。
