电子给体-受体连接分子对膜电位的近红外光调控。

Near-infrared light control of membrane potential by an electron donor-acceptor linked molecule.

机构信息

Research Institute for Electronic Science, Hokkaido University, Kita-20, Nishi-10, Sapporo 001-0020, Japan.

Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan.

出版信息

Chem Commun (Camb). 2020 Oct 20;56(83):12562-12565. doi: 10.1039/d0cc05326k.

DOI:10.1039/d0cc05326k

PMID:32940286

Abstract

Near-infrared (NIR) light control of living cellular activities is a highly desired technique for living cell manipulation because of its advantage of high penetrability towards living tissue. In this study, (π-extended porphyrin)-fullerene linked molecules are designed and synthesized to achieve NIR light control of the membrane potential. A donor-(π-extended porphyrin)-acceptor linked molecule exhibited the formation of the charge-separated state with a relatively long lifetime (0.68 μs) and a moderate quantum yield (27-31%). The hydrophilic trimethylammonium-linked triad molecule successfully altered PC12 cells' membrane potential via photoinduced intramolecular charge separation.

摘要

近红外（NIR）光控制活细胞活动是一种非常需要的活细胞操作技术，因为它具有对活组织高穿透性的优势。在这项研究中，设计并合成了（π-扩展卟啉）-富勒烯连接分子，以实现对膜电位的近红外光控制。供体-（π-扩展卟啉）-受体连接分子表现出形成电荷分离态，具有相对较长的寿命（0.68 μs）和中等的量子产率（27-31%）。亲水性三甲铵连接三联体分子通过光诱导分子内电荷分离成功改变了 PC12 细胞的膜电位。