Scala R A
Exxon Biomedical Sciences, Incorporated, East Millstone, New Jersey 08873.
Fundam Appl Toxicol. 1988 May;10(4):553-62.
The toxicology of motor gasoline is reviewed and the subject considered in two ways. First is as a problem involving a widely used commodity material and the second as a model for the study of complex mixtures. Previously reported subchronic and chronic inhalation studies showing primarily nephrotoxicity in male rats are summarized. Questions of experimental design are discussed including sample verification, species, and dose selection and choice of exposure circumstances. Low boiling, highly branched hydrocarbons primarily in the 6 to 10 carbon number range are implicated. Still unanswered is the basis for the response in male rats only and the precise mechanism of action.
本文对车用汽油的毒理学进行了综述，并从两个方面对该主题进行了探讨。一是将其视为一个涉及广泛使用的商品材料的问题，二是将其作为研究复杂混合物的模型。本文总结了先前报道的亚慢性和慢性吸入研究，这些研究主要显示雄性大鼠存在肾毒性。文中讨论了实验设计问题，包括样本验证、物种、剂量选择以及暴露环境的选择。主要涉及碳数在6至10范围内的低沸点、高度支链化的烃类。仅在雄性大鼠中出现反应的原因以及确切的作用机制仍未得到解答。
