STAR-超声大腿调整比：肌少症诊断的黄金公式。

STAR-Sonographic Thigh Adjustment Ratio: A Golden Formula for the Diagnosis of Sarcopenia.

机构信息

From the Department of Physical and Rehabilitation Medicine, Hacettepe University Medical School, Ankara, Turkey (MK, BK, AB, LÖ) Department of Physical and Rehabilitation Medicine, Doctor Ayten Bozkaya Spastic Children Hospital and Rehabilitation Center, Bursa, Turkey (AMA); Hacettepe University, Faculty of Physical Therapy and Rehabilitation, Ankara, Turkey (ÖÖ, ST); Geriatrics Unit, Yenimahalle Training and Research Hospital, Yıldırım Beyazıt University, Ankara, Turkey (ÖK); Department of Geriatrics, Hacettepe University Medical School, Ankara, Turkey (GŞA, MH); Department of Biostatistics, Hacettepe University Medical School, Ankara, Turkey (SK); Department of Biophysics, Hacettepe University Medical School, Ankara, Turkey (ARS); and Department of Public Health, Hacettepe University Medical School, Ankara, Turkey (BÇ).

出版信息

Am J Phys Med Rehabil. 2020 Oct;99(10):902-908. doi: 10.1097/PHM.0000000000001439.

DOI:10.1097/PHM.0000000000001439

PMID:32941253

Abstract

OBJECTIVE

The aim of the study was to explore an individualized sonographic muscle thickness ratio and its cutoff values in the diagnosis of sarcopenia.

DESIGN

A total of 326 community-dwelling adults were included in this cross-sectional study. Total skeletal muscle mass was evaluated by bioelectrical impedance analysis, and nine-site muscle thickness measurements using ultrasound. Isometric handgrip and knee extension strengths were assessed. Physical performance was evaluated by usual Gait Speed, Chair Stand Test, and Timed Up and Go Test.

RESULTS

Because the anterior thigh muscle thickness was the most significantly decreasing measurement with aging and the most significantly related value with body mass and height; sonographic thigh adjustment ratio was calculated by dividing it with body mass index. Using the two standard deviation values of our healthy young adults, sonographic thigh adjustment ratio cutoff values were found as 1.4 and 1.0 for male and female subjects, respectively. Sonographic thigh adjustment ratio values were negatively correlated with Chair Stand Test and Timed Up and Go Test in both sexes (all P < 0.05) and positively correlated with gait speed in female subjects and knee extension strength in male subjects (both P < 0.05).

CONCLUSIONS

Our results imply that regional (rather than total) muscle mass measurements should be taken into consideration for the diagnosis of sarcopenia.

摘要

目的

本研究旨在探讨一种个体化的超声肌肉厚度比及其在诊断肌少症中的截断值。

设计

本横断面研究共纳入 326 名社区居住的成年人。通过生物电阻抗分析法评估总体骨骼肌质量，并使用超声测量九部位肌肉厚度。评估等长握力和膝关节伸展力。通过常规步态速度、坐立试验和起立-行走测试评估身体机能。

结果

由于股前肌厚度是随年龄增长变化最显著的测量指标，也是与体重和身高最相关的指标；因此，通过将其除以体重指数来计算超声股部调整比。使用我们健康年轻成年人的两个标准差值，发现男性和女性受试者的超声股部调整比截断值分别为 1.4 和 1.0。在两性中，超声股部调整比与坐立试验和起立-行走测试呈负相关（均 P < 0.05），与女性受试者的步态速度和男性受试者的膝关节伸展力呈正相关（均 P < 0.05）。