Niveditha Y, Bishop N, Boyle R M, Stoker J B, Mary D A
Department of Cardiovascular Studies, Leeds University, U.K.
Int J Cardiol. 1988 Jun;19(3):341-54. doi: 10.1016/0167-5273(88)90239-2.
The effect of isosorbide dinitrate or indoramin on myocardial ischaemia was examined in patients with stable angina pectoris. In a prospective trial, randomization resulted in 8 and 9 patients, respectively, given isosorbide dinitrate in a dose of 30-90 mg daily, and indoramin in a dose of 75-225 mg daily; 2 of these patients were serially examined during the two types of therapy. Changes in myocardial ischaemia were assessed by exercise testing using 12 standard electrocardiographic leads and a bipolar lead CM5. Individual and group comparisons showed that isosorbide dinitrate resulted in an increase in ST segment depression, the maximal ST/heart rate slope and the ratio of net ST segment depression to increases in heart rate (at least P less than 0.01). In contrast, with indoramin therapy there were no significant changes in these indices. The results in these patients suggest that isosorbide dinitrate leads more consistently to increases in the severity of myocardial ischaemia than indoramin, although this effect on ischaemia is apparently less than the benefit of these agents on exercise performance.
在稳定型心绞痛患者中研究了硝酸异山梨酯或吲哚拉明对心肌缺血的影响。在一项前瞻性试验中，随机分组后，分别有8例和9例患者接受每日30 - 90毫克剂量的硝酸异山梨酯和每日75 - 225毫克剂量的吲哚拉明治疗；其中2例患者在两种治疗期间接受了连续检查。通过使用12个标准心电图导联和一个双极导联CM5的运动试验评估心肌缺血的变化。个体和组间比较显示，硝酸异山梨酯导致ST段压低、最大ST/心率斜率以及净ST段压低与心率增加之比升高（至少P小于0.01）。相比之下，使用吲哚拉明治疗时，这些指标无显著变化。这些患者的结果表明，与吲哚拉明相比，硝酸异山梨酯更一致地导致心肌缺血严重程度增加，尽管这种对缺血的影响明显小于这些药物对运动能力的益处。
