Department of Pharmacology and Toxicology, Faculty of Medicine, UWM, 10-082, Olsztyn, Poland.
Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Łódź, 90-236, Łódź, Poland.
J Ethnopharmacol. 2021 Jan 30;265:113393. doi: 10.1016/j.jep.2020.113393. Epub 2020 Sep 14.
Taraxacum officinale (L.), commonly called dandelion has been used for centuries as a natural medicine to treat inflammatory diseases including some metabolic alterations associated with obesity.
Based on animal experiments this study aims to explore the potential mechanisms of action of T. officinale flower water syrup (TOFS) together with a normal-fat diet in the intervention of obesity.
Obese male albino-Wistar rats (n = 8) at 25 weeks of age were fed with a normal-fat diet with or without added 27.82% TOFS (w/w) for 4 weeks. The reactivity of thoracic aorta and antioxidant capacity were studied.
TOFS delivered daily 926.8 μg of L-chicoric acid, 20.19 μg of luteolin and 3.379 g of sucrose. TOFS showed beneficial effects by regulating blood lipids (HDL, x1.11-fold increase), thereby lowering the risk factors for atherosclerosis (TC/HDL, x0.90-fold). The antioxidant status was improved via an increase in plasma superoxide radical scavenging (SOD, x1.6-fold) and a decrease in lipid peroxidation (MDA, x0.81-fold). Moreover, the following were decreased: Cu (x0.53-fold), Zn (x0.72-fold) and the Cu/Zn molar ratio (x0.60-fold). A marker for liver damage/disease was beneficially decreased (ALP, x0.87-fold). TOFS modulated in a significant way COX-depended relaxation to ACh (p = 0.05) but not to CORM-2 (p = 0.1651) in isolated thoracic arteries, by decreased participation of vasoconstrictor prostanoids. The vascular contraction to prostaglandin F was also decreased (x0.62-fold). We observed no change in the feed intake, body weight, organ-to-body weight ratio, blood glucose, CAT, FRAP, AST, ALT, TBARS/carbonyls (in heart, liver, kidneys, spleen) and carbonyls (in blood plasma, thoracic arteries); as well as F-isoprostanes in urine. Vascular response to the vasodilators ACh, SNP, A23187, CORM-2, pinacidil, NS-1619 and to the vasoconstrictors NA, U-46619, ET-1 as well as hyperpolarizing mechanism(s) were not modified.
TOFS possesses beneficial properties by regulating prostanoids and antioxidant status.
蒲公英（Taraxacum officinale（L.））作为一种天然药物，已被使用了数个世纪，用于治疗炎症性疾病，包括与肥胖相关的一些代谢紊乱。
基于动物实验，本研究旨在探索蒲公英花水糖浆（TOFS）与正常脂肪饮食联合干预肥胖的潜在作用机制。
25 周龄雄性白化 Wistar 大鼠（n=8）喂食正常脂肪饮食，或添加 27.82%TOFS（w/w）的正常脂肪饮食，持续 4 周。研究了胸主动脉的反应性和抗氧化能力。
TOFS 每天提供 926.8μg 的 L-菊苣酸、20.19μg 的木犀草素和 3.379g 的蔗糖。TOFS 通过调节血脂（HDL，增加 1.11 倍），从而降低动脉粥样硬化的风险因素（TC/HDL，降低 0.90 倍），显示出有益的效果。通过增加血浆超氧化物歧化酶（SOD，增加 1.6 倍）和降低脂质过氧化（MDA，降低 0.81 倍），抗氧化状态得到改善。此外，铜（Cu，降低 0.53 倍）、锌（Zn，降低 0.72 倍）和 Cu/Zn 摩尔比（降低 0.60 倍）降低。肝损伤/疾病标志物（ALP）降低 0.87 倍。TOFS 以显著方式调节 COX 依赖性松弛对 ACh（p=0.05）但对 CORM-2（p=0.1651）的反应，通过减少血管收缩性前列腺素的参与。对前列腺素 F 的血管收缩也降低（降低 0.62 倍）。我们观察到饮食摄入、体重、器官与体重比、血糖、CAT、FRAP、AST、ALT、TBARS/羰基（心脏、肝脏、肾脏、脾脏）和羰基（血浆、胸主动脉）以及尿液中的 F-异前列腺素无变化。血管舒张剂 ACh、SNP、A23187、CORM-2、pinacidil、NS-1619 和血管收缩剂 NA、U-46619、ET-1 的血管反应以及超极化机制均未改变。
TOFS 通过调节前列腺素和抗氧化状态具有有益的特性。
