Ghezzaz Amina, Cristea Cristina, Ferradji Amel, Aboubekr El Habib, Bouhanna-Hamitouche Lynda, Chahed Sadri, Mahdjoubi Amir
Ophthalmology Department.
Neurology Department.
Neurol Int. 2020 Sep 1;12(2):8558. doi: 10.4081/ni.2020.8558. eCollection 2020 Aug 18.
A 70-year-old man presented to the emergency department with blood hypotension associated to a sudden paraplegia and thermalgesic analgesia. He had an history of colic and prostatic adenocarcinoma, hypertension and non-dialyzed Chronic Kidney Disease (CKD) related to an idiopathic membranous glomerulonephritis type 1 discovered 9 years ago. Magnetic resonance imaging confirmed a diagnosis of Spinal Cord Infarction (SCI). Few months later, he presented a blurred vision due to central Retinal Vein Occlusion (RVO), which was improved by Anti-VEGF therapy. This is the first reported case of a concomitance of retinal vascular event and SCI highlights the links between the central nervous system and retinal vascularization despite separate involvement of the two events in the arterial and venous systems. Additionally, CKD worsened the risk of cardiovascular incidents by induced oxidative stress, thrombophilia, chronic inflammation, and endothelial dysfunction. SCI occurrence indicates severe vascular dysfunction and elevates the risk of additional vascular disorders.
一名70岁男性因突发截瘫和热痛觉缺失伴血压降低被送至急诊科。他有绞痛和前列腺腺癌病史，患高血压以及9年前因特发性1型膜性肾小球肾炎导致的非透析慢性肾脏病（CKD）。磁共振成像确诊为脊髓梗死（SCI）。几个月后，他因中心性视网膜静脉阻塞（RVO）出现视力模糊，经抗血管内皮生长因子（Anti-VEGF）治疗后有所改善。这是首例报告的视网膜血管事件与脊髓梗死同时发生的病例，突出了尽管这两个事件分别累及动脉和静脉系统，但中枢神经系统与视网膜血管形成之间的联系。此外，慢性肾脏病通过诱导氧化应激、血栓形成倾向、慢性炎症和内皮功能障碍，增加了心血管事件的风险。脊髓梗死的发生表明严重的血管功能障碍，并增加了发生其他血管疾病的风险。
