Yang Chun, Xi Yin, Chen Wen-Ying, Sang Lin, Liu Dong-Dong, Zhang Rong, Chen Si-Bei, Zhang Jie, Pan Jie-Yi, Xv Yong-Hao, Nong Lin-Bo, Li Yi-Min, Liu Xiao-Qing
State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
J Thorac Dis. 2020 Aug;12(8):4292-4298. doi: 10.21037/jtd-20-1191.
To investigate the conversion ratio of tacrolimus switching from intravenous infusion to oral administration in patients after lung transplantation.
We retrospectively recruited patients received lung transplantation in the First Affiliated Hospital of Guangzhou Medical Hospital from January 2015 to June 2019. The blood concentration of tacrolimus administrated through intravenous infusion and oral administration were collected. The blood concentration, concentration/dose ratio (C/D), and (C/Dpo)/(C/Div) ratio were analyzed to explore the conversion ratio of tacrolimus switching from intravenous infusion to oral administration, as combined medication of tacrolimus and caspofungin were used.
The concentration of intravenously administered tacrolimus was significantly higher than that of oral administration; the C/D ratio of intravenously administrated tacrolimus (C/Div) was significantly higher than that of the oral administration (C/Dpo). There was a significant correlation between C/Dpo and C/Div (R =0.774, P<0.001). The conversion ratio of tacrolimus from intravenous administration to oral administration was 1:7.4, as combined medication of tacrolimus and caspofungin were used.
The conversion ratio of tacrolimus switching from intravenous to oral administration is 1:7.4 in the combination treatment of tacrolimus and caspofungin after lung transplantation.
探讨肺移植术后患者他克莫司从静脉输注转换为口服给药的转换比例。
回顾性纳入2015年1月至2019年6月在广州医科大学附属第一医院接受肺移植的患者。收集静脉输注和口服他克莫司后的血药浓度。分析血药浓度、浓度/剂量比（C/D）以及（C/Dpo）/（C/Div）比，以探讨他克莫司从静脉输注转换为口服给药的转换比例，因为使用了他克莫司与卡泊芬净的联合用药。
静脉输注他克莫司的浓度显著高于口服给药；静脉输注他克莫司的C/D比（C/Div）显著高于口服给药（C/Dpo）。C/Dpo与C/Div之间存在显著相关性（R = 0.774，P < 0.001）。在使用他克莫司与卡泊芬净联合用药的情况下，他克莫司从静脉给药转换为口服给药的转换比例为1:7.4。
在肺移植后他克莫司与卡泊芬净联合治疗中，他克莫司从静脉给药转换为口服给药的转换比例为1:7.4。
