Johnston Andrea N, Wang Zhigao
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.
Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Mol Cell Oncol. 2020 Jul 14;7(5):1791561. doi: 10.1080/23723556.2020.1791561. eCollection 2020.
Mixed lineage kinase domain-like protein (MLKL) is the proposed executioner of necroptosis. Our recent findings identify a novel inhibitor necroptosis-blocking compound 1 (NBC1) which specifically conjugates to two cysteines of heat shock protein 70 (HSP70) to block its function. Importantly, HSP70 promotes MLKL polymerization to activate necroptosis.
混合谱系激酶结构域样蛋白（MLKL）被认为是坏死性凋亡的执行者。我们最近的研究发现了一种新型坏死性凋亡阻断化合物1（NBC1），它能特异性地与热休克蛋白70（HSP70）的两个半胱氨酸结合，从而阻断其功能。重要的是，HSP70促进MLKL聚合以激活坏死性凋亡。
