通过让旧药物发挥新作用来克服对免疫疗法的耐药性。
Overcoming resistance to immunotherapy by teaching old drugs new tricks.
作者信息
Perry John M, Li Linheng
机构信息
Children's Mercy Kansas City, Kansas City, MO, USA.
University of Kansas Medical Center, Kansas City, KS, USA.
出版信息
Mol Cell Oncol. 2020 Aug 12;7(5):1801088. doi: 10.1080/23723556.2020.1801088. eCollection 2020.
Abstract
Cancer stem cells (CSCs) underlie resistance to therapy. Cancer develops only in the context of failing immunosurveillance, and stem cells occupy immune privileged microenvironments. Recent evidence demonstrates that CSCs borrow immune privilege from their normal counterparts. However, low doses of doxorubicin can target CSCs by restoring anticancer immunity.
摘要
癌症干细胞（CSCs）是治疗耐药的基础。癌症仅在免疫监视功能失效的情况下发生，并且干细胞占据免疫豁免微环境。最近的证据表明，癌症干细胞从其正常对应物那里获得免疫豁免。然而，低剂量的阿霉素可以通过恢复抗癌免疫力来靶向癌症干细胞。
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