Seyfer A E, Zajtchuk R, Hazlett D R, Mologne L A
Surg Gynecol Obstet. 1977 Sep;145(3):401-7.
Sixteen dogs were studied in an effort to investigate certain peripheral vascular and metabolic parameters in endotoxic shock. Cardiopulmonary bypass was instituted for 12 of the dogs to study systemic parameters at constant circulatory flow rates. From these studies, it appears that endotoxin is capable of initiating profound hemodynamic and metabolic changes. Initially, cardiac output and arterial pressure drop precipitiously, despite a transient rise in systemic and pulmonary vascular resistance. Subsequently, peripheral arterial pressures and systemic vascular resistance continue to decline, even if arterial flow remains at constant levels. Oxygen extraction by peripheral tissues decreases after endotoxin injection, despite adequate oxygen availability and constant hemoglobin levels.
为了研究内毒素休克中的某些外周血管和代谢参数，对16只狗进行了研究。对其中12只狗实施了体外循环，以在恒定循环流速下研究全身参数。从这些研究来看，内毒素似乎能够引发深刻的血流动力学和代谢变化。最初，尽管全身和肺血管阻力短暂升高，但心输出量和动脉压急剧下降。随后，即使动脉血流量保持在恒定水平，外周动脉压和全身血管阻力仍继续下降。内毒素注射后，尽管有足够的氧供应且血红蛋白水平恒定，但外周组织的氧摄取仍会减少。
