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[枸橼酸镓67的热成像和闪烁扫描术在口腔及咽旁肿瘤诊断中的应用]

[Thermo- and scintigraphy with 67Ga citrate in the diagnosis of oro- and parapharyngeal tumors].

作者信息

Gabunov R I, Kurbandurdyev A G, Lenskaia O P, Bogdasarov Iu V

出版信息

Med Radiol (Mosk). 1988 Jul;33(7):9-14.

PMID:3294558
Abstract

The authors analyzed the results of thermographic and scintigraphic (using 67Ga-citrate produced in the USSR) investigations in 41 patients: 10 with tumors of the oral cavity, 12 with oropharyngeal tumors, and 19 with parapharyngeal tumors. Of the latter 10 had morphologically verified benign tumors, 5--mixed type tumors, and 4--malignant tumors (sarcoma in 2 patients, a thyroid cancer metastasis to the parapharyngeal lymph nodes in 1, malignant chemodectoma in 1). Thermography and scintigraphy positive results (the absence of hyperthermia and RP hyperfixation in a tumor) were obtained in 7 of 10 patients with benign parapharyngeal tumors. Thermography false-positive results were obtained in 3 patients, however 67Ga-citrate accumulation was undetectable in these patients' tumors making the diagnosis more accurate. Thermography and scintigraphy results were positive in all 22 patients with malignant oropharyngeal (the oral cavity and oropharynx) tumors. Thermography and scintigraphy positive results were also noted in all 5 patients with parapharyngeal mixed tumors which could be associated with raised tumor tissue biological activity. The data obtained suggested a possibility of the use of thermography and scintigraphy in the diagnosis of oro-and parapharyngeal tumors.

摘要

作者分析了41例患者的热成像和闪烁扫描(使用苏联生产的枸橼酸镓67)检查结果:10例口腔肿瘤患者,12例口咽肿瘤患者,19例咽旁肿瘤患者。在后者中,10例经形态学证实为良性肿瘤,5例为混合型肿瘤,4例为恶性肿瘤(2例为肉瘤,1例为甲状腺癌转移至咽旁淋巴结,1例为恶性化学感受器瘤)。10例良性咽旁肿瘤患者中有7例热成像和闪烁扫描结果为阳性(肿瘤无热疗和放射性核素高摄取)。3例患者出现热成像假阳性结果,然而在这些患者的肿瘤中未检测到枸橼酸镓67的蓄积,从而使诊断更加准确。22例恶性口咽(口腔和口咽)肿瘤患者的热成像和闪烁扫描结果均为阳性。5例咽旁混合型肿瘤患者的热成像和闪烁扫描结果也为阳性,这可能与肿瘤组织生物活性升高有关。所获得的数据表明热成像和闪烁扫描在口腔和咽旁肿瘤诊断中具有应用可能性。

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